caa a22 4500 467940185 CHVBK 20180406153010.0 cr unu---uuuuu 170328e20061001xx s 000 0 eng 10.1007/s00421-006-0281-y doi (NATIONALLICENCE)springer-10.1007/s00421-006-0281-y Effect of training and detraining on the expression of heat shock proteins in m. triceps brachii of untrained males and females [Elektronische Daten] [Terje Gjøvaag, Hans Dahl] Forty untrained persons were randomized to four different training protocols that exercised the m. triceps brachii. Group 1 and 2 performed high intensity (HI) elbow extensions and group 3 and 4 performed low intensity (LI) elbow extensions. Group 1 and 3 trained until they had accumulated a matching high volume (HV) of training, while group 2 and 4 trained until they had accumulated a matching low volume (LV) of training. Training for 5-8weeks increased the HSP72, HSP27 and GRP75 levels in the subjects' m. triceps brachii by 111, 71 and 192%, respectively (Fig.1a-c). There were, however, no significant differences in the heat shock protein (HSP) responses to training between the four training groups (Fig.2a-c). The frequency of extreme responses to exercise was, however, higher after HI exercise than after LI exercise, indicating that HI exercise induces extreme HSP reactions in some subjects. When we assigned the subjects to three clusters, according to the total number of repetitions they had lifted, the subjects who had lifted the highest number of repetitions had lower PostExc HSP levels compared with subjects that lifted the lowest number of repetitions (Fig.3a-c). Additionally, there was a negative non-linear regression (Fig.4a-c) between the subjects PreExc levels of HSP72, HSP27 and GRP75 and the percentage change in their respective protein concentration after training (r=−0.75, −0.89 and −0.88, all P<0.0001). Thus, the PreExc level of HSPs seems to be an important "regulator” of HSP expression following the training. Springer-Verlag, 2006 HSP72 nationallicence HSP27 nationallicence GRP75 nationallicence Intensity nationallicence Volume nationallicence Duration nationallicence Untrained muscle nationallicence Gjøvaag Terje Oslo University College, St Olavs Plass, PO Box 4, 0130, Oslo, Norway aut Dahl Hans Institute of Basic Medical Sciences, Department of Anatomy, University of Oslo, Blindern, PO Box 1105, 0317, Oslo, Norway aut European Journal of Applied Physiology Springer-Verlag 98/3(2006-10-01), 310-322 1439-6319 98:3<310 2006 98 421 https://doi.org/10.1007/s00421-006-0281-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0281-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gjøvaag Terje Oslo University College, St Olavs Plass, PO Box 4, 0130, Oslo, Norway aut NATIONALLICENCE 700 1- Dahl Hans Institute of Basic Medical Sciences, Department of Anatomy, University of Oslo, Blindern, PO Box 1105, 0317, Oslo, Norway aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 98/3(2006-10-01), 310-322 1439-6319 98:3<310 2006 98 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer