caa a22 4500 467940231 CHVBK 20180406153010.0 cr unu---uuuuu 170328e20061101xx s 000 0 eng 10.1007/s00421-006-0282-x doi (NATIONALLICENCE)springer-10.1007/s00421-006-0282-x Isometric handgrip training improves local flow-mediated dilation in medicated hypertensives [Elektronische Daten] [Cheri McGowan, Adrienne Visocchi, Martha Faulkner, Robin Verduyn, Mark Rakobowchuk, Andrew Levy, Neil McCartney, Maureen MacDonald] Bilateral isometric handgrip (IHG) training lowers resting arterial blood pressure (BP) in medicated hypertensives. Numerous mechanisms have been suggested, but have yet to be investigated. One such mechanism is that of improved systemic endothelial-dependent vasodilation. The purpose of this investigation was twofold: (1) to determine if Bilateral IHG training had any beneficial effects on endothelial-dependent vasodilation, and (2) to see if improved systemic endothelial-dependent vasodilation was responsible for lowering BP. Sixteen participants performed four, 2min IHG contractions at 30% of their maximal voluntary effort, using either a Bilateral (n=7) or a Unilateral IHG protocol (n=9), three timesper week for 8weeks. Brachial artery (BA) flow-mediated dilation (FMD, an index of endothelial-dependent vasodilation, measured in both arms) was assessed pre-and post-training. Following Bilateral IHG training, BA FMD improved in both arms (normalized to peak shear rate, 0.005±0.001 to 0.02±0.002 s−1, P<0.01). Following Unilateral IHG training, BA FMD improved in the trained arm only (normalized: 0.009±0.002 to 0.02±0.005s−1, P<0.01). These findings suggest that although IHG training improves endothelial-dependent vasodilation, the improvements occur only locally in the trained limbs. This suggests that enhanced systemic endothelial-dependent vasodilation is not the mechanism responsible for the observed post-IHG training reductions in BP in medicated hypertensives. Springer-Verlag, 2006 Endothelium nationallicence Exercise nationallicence Hypertension nationallicence Blood flow nationallicence McGowan Cheri Department of Kinesiology, McMaster University, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada aut Visocchi Adrienne Department of Kinesiology, McMaster University, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada aut Faulkner Martha Department of Kinesiology, McMaster University, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada aut Verduyn Robin Department of Kinesiology, McMaster University, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada aut Rakobowchuk Mark Department of Kinesiology, McMaster University, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada aut Levy Andrew Department of Kinesiology, McMaster University, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada aut McCartney Neil Department of Kinesiology, McMaster University, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada aut MacDonald Maureen Department of Kinesiology, McMaster University, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada aut European Journal of Applied Physiology Springer-Verlag 98/4(2006-11-01), 355-362 1439-6319 98:4<355 2006 98 421 https://doi.org/10.1007/s00421-006-0282-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0282-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McGowan Cheri Department of Kinesiology, McMaster University, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Visocchi Adrienne Department of Kinesiology, McMaster University, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Faulkner Martha Department of Kinesiology, McMaster University, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Verduyn Robin Department of Kinesiology, McMaster University, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Rakobowchuk Mark Department of Kinesiology, McMaster University, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- Levy Andrew Department of Kinesiology, McMaster University, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- McCartney Neil Department of Kinesiology, McMaster University, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada aut NATIONALLICENCE 700 1- MacDonald Maureen Department of Kinesiology, McMaster University, 1280 Main Street West, L8S 4K1, Hamilton, ON, Canada aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 98/4(2006-11-01), 355-362 1439-6319 98:4<355 2006 98 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 457603291 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer