caa a22 4500 467940258 CHVBK 20180406153010.0 cr unu---uuuuu 170328e20061101xx s 000 0 eng 10.1007/s00421-006-0299-1 doi (NATIONALLICENCE)springer-10.1007/s00421-006-0299-1 The effect of 18h of simulated high altitude on left ventricular function [Elektronische Daten] [Jesper Kjaergaard, Eric Snyder, Christian Hassager, Thomas Olson, Jae Oh, Bruce Johnson] High altitude produces increased pulmonary capillary pressure by hypoxia induced pulmonary vasoconstriction. It is also possible that hypoxia results in mildly elevated left ventricular (LV) filling pressures that may contribute to the elevated capillary pressures. This study investigates the impact of simulated high altitude on global and regional echocardiographic measures of LV performance and filling pressure. Seventeen healthy individuals underwent transthoracic echocardiography, including tissue Doppler of the septal mitral annulus and basal segments before and after an 18-h overnight stay in a high altitude simulation tent with a FiO2 of 12%, simulating an altitude of approximately 4,000m above sea level. In simulated high altitude, the ratio of early transmitral flow velocity to early myocardial relaxation velocity increased 22%, P<0.001, and the Index of Myocardial Performance increased 30%, P<0.01 due to an 58% increase in the isovolumic relaxation time (IVRT), P<0.001. Simulated high altitude leads to a reduction in LV performance with an accompanying increase in markers of LV filling pressure. The significant changes in filling pattern and IVRT in the setting of normal and unchanged systolic function, indicates that hypoxia induces mild diastolic dysfunction in young healthy individuals. Springer-Verlag, 2006 Hypoxia nationallicence Cardiac function nationallicence Diastole nationallicence Kjaergaard Jesper Department of Cardiology, Copenhagen University Hospital Rigshospitalet, 2100, Copenhagen Ø, Denmark aut Snyder Eric Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN, USA aut Hassager Christian Department of Cardiology, Copenhagen University Hospital Rigshospitalet, 2100, Copenhagen Ø, Denmark aut Olson Thomas Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN, USA aut Oh Jae Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN, USA aut Johnson Bruce Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN, USA aut European Journal of Applied Physiology Springer-Verlag 98/4(2006-11-01), 411-418 1439-6319 98:4<411 2006 98 421 https://doi.org/10.1007/s00421-006-0299-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0299-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kjaergaard Jesper Department of Cardiology, Copenhagen University Hospital Rigshospitalet, 2100, Copenhagen Ø, Denmark aut NATIONALLICENCE 700 1- Snyder Eric Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Hassager Christian Department of Cardiology, Copenhagen University Hospital Rigshospitalet, 2100, Copenhagen Ø, Denmark aut NATIONALLICENCE 700 1- Olson Thomas Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Oh Jae Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 700 1- Johnson Bruce Division of Cardiovascular Diseases, Mayo Clinic College of Medicine, 200 First Street SW, 55905, Rochester, MN, USA aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 98/4(2006-11-01), 411-418 1439-6319 98:4<411 2006 98 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer