caa a22 4500 467940266 CHVBK 20180406153010.0 cr unu---uuuuu 170328e20061101xx s 000 0 eng 10.1007/s00421-006-0294-6 doi (NATIONALLICENCE)springer-10.1007/s00421-006-0294-6 Effect of regular exercise on homocysteine concentrations: the HERITAGE Family Study [Elektronische Daten] [Tomohiro Okura, Tuomo Rankinen, Jacques Gagnon, Suzanne Lussier-Cacan, Jean Davignon, Arthur Leon, D. Rao, James Skinner, Jack Wilmore, Claude Bouchard] We investigated whether regular aerobic exercise could affect plasma total homocysteine (tHcy), and whether there were sex-related or racial differences in tHcy changes. Data were available for 816 black and white men and women, aged 17-65years, 711 of whom completed a 20week aerobic exercise training program. The tHcy concentration was measured in frozen plasma samples by an HPLC method. In Blacks, tHcy did not change with exercise training [men −0.5 (SD 3.7)μmol/l, women 0.0 (2.2)μmol/l) but increased significantly in Whites (men +0.3 (1.7)μmol/l, women +0.2 (1.6)μmol/l). No sex-related differences were found in either racial group. Changes in tHcy correlated negatively with baseline homocysteine (r=−0.40, P<0.0001). Homocysteine levels of the "High” (hyperhomocysteinemia) (≥15μmol/l) group (n=30) decreased significantly with regular aerobic exercise from 23.1 (12.1) to 19.6 (7.6)μmol/l. Homocysteine levels of the "Normal” group increased slightly from 8.2±2.2 to 8.5±2.4μmol/l. Men exhibit racial differences for tHcy responses to exercise training. Regular aerobic exercise has favorable effects on individuals with hyperhomocysteinemia, but tHcy slightly increased in individuals within the normal range. Springer-Verlag, 2006 Aerobic exercise training nationallicence Sex nationallicence Homocysteine nationallicence Hyperhomocysteinemia nationallicence Racial differences nationallicence Okura Tomohiro Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, 70808, Baton Rouge, LA, USA aut Rankinen Tuomo Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, 70808, Baton Rouge, LA, USA aut Gagnon Jacques Marine Biotechnology Research Centre, Remouski, Quebec, Canada aut Lussier-Cacan Suzanne Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Montreal, Quebec, Canada aut Davignon Jean Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Montreal, Quebec, Canada aut Leon Arthur Division of Kinesiology, University of Minnesota, Minneapolis, MN, USA aut Rao D. Division of Biostatistics and Departments of Genetics and Psychiatry, Washington University Medical School, St Louis, MO, USA aut Skinner James Department of Kinesiology, Indiana University, Bloomington, IN, USA aut Wilmore Jack Department of Kinesiology and Health Education, University of Texas at Austin, Austin, TX, USA aut Bouchard Claude Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, 70808, Baton Rouge, LA, USA aut European Journal of Applied Physiology Springer-Verlag 98/4(2006-11-01), 394-401 1439-6319 98:4<394 2006 98 421 https://doi.org/10.1007/s00421-006-0294-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0294-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Okura Tomohiro Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, 70808, Baton Rouge, LA, USA aut NATIONALLICENCE 700 1- Rankinen Tuomo Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, 70808, Baton Rouge, LA, USA aut NATIONALLICENCE 700 1- Gagnon Jacques Marine Biotechnology Research Centre, Remouski, Quebec, Canada aut NATIONALLICENCE 700 1- Lussier-Cacan Suzanne Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Davignon Jean Hyperlipidemia and Atherosclerosis Research Group, Clinical Research Institute of Montreal, Montreal, Quebec, Canada aut NATIONALLICENCE 700 1- Leon Arthur Division of Kinesiology, University of Minnesota, Minneapolis, MN, USA aut NATIONALLICENCE 700 1- Rao D. Division of Biostatistics and Departments of Genetics and Psychiatry, Washington University Medical School, St Louis, MO, USA aut NATIONALLICENCE 700 1- Skinner James Department of Kinesiology, Indiana University, Bloomington, IN, USA aut NATIONALLICENCE 700 1- Wilmore Jack Department of Kinesiology and Health Education, University of Texas at Austin, Austin, TX, USA aut NATIONALLICENCE 700 1- Bouchard Claude Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, 70808, Baton Rouge, LA, USA aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 98/4(2006-11-01), 394-401 1439-6319 98:4<394 2006 98 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer