caa a22 4500 467940282 CHVBK 20180406153010.0 cr unu---uuuuu 170328e20061101xx s 000 0 eng 10.1007/s00421-006-0271-0 doi (NATIONALLICENCE)springer-10.1007/s00421-006-0271-0 Effect of multiple oral doses of androgenic anabolic steroids on endurance performance and serum indices of physical stress in healthy male subjects [Elektronische Daten] [Norbert Baume, Yorck Schumacher, Pierre-Edouard Sottas, Carlo Bagutti, Michel Cauderay, Patrice Mangin, Martial Saugy] Anabolic androgenic steroids (AAS) are doping agents that are mostly used for improvement of strength and muscle hypertrophy. In some sports, athletes reported that the intake of AAS is associated with a better recovery, a higher training load capacity and therefore an increase in physical and mental performances. The purpose of this study was to evaluate, the effect of multiple doses of AAS on different physiological parameters that could indirectly relate the physical state of athletes during a hard endurance training program. In a double blind settings, three groups (n=9, 8 and 8) were orally administered placebo, testosterone undecanoate or 19-norandrostenedione, 12 times during 1month. Serum biomarkers (creatine kinase, ASAT and urea), serum hormone profiles (testosterone, cortisol and LH) and urinary catecholamines (noradrenalin, adrenalin and dopamine) were evaluated during the treatment. Running performance was assessed before and after the intervention phase by means of a standardized treadmill test. None of the measured biochemical variables showed significant impact of AAS on physical stress level. Data from exercise testing on submaximal and maximal level did not reveal any performance differences between the three groups or their response to the treatment. In the present study, no effect of multiple oral doses of AAS on endurance performance or bioserum recovery markers was found. Springer-Verlag, 2006 Anabolic androgenic steroids nationallicence Doping nationallicence Recovery nationallicence Endurance training nationallicence Running nationallicence Baume Norbert Laboratoire Suisse d'Analyse du Dopage, Institut Universitaire de Médecine Légale, Ch. des Croisettes 22, 1066, Epalinges, Switzerland aut Schumacher Yorck Abtlg. Sportmedizin, Medizinische Universitätsklinik Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany aut Sottas Pierre-Edouard Laboratoire Suisse d'Analyse du Dopage, Institut Universitaire de Médecine Légale, Ch. des Croisettes 22, 1066, Epalinges, Switzerland aut Bagutti Carlo Centre Médical Vidy-Med, Rte de Chavannes 11, 1000, Lausanne 23, Switzerland aut Cauderay Michel Hôpital Riviera, Site du Samaritain, Bd. Paderewski 3, 1800, Vevey, Switzerland aut Mangin Patrice Laboratoire Suisse d'Analyse du Dopage, Institut Universitaire de Médecine Légale, Ch. des Croisettes 22, 1066, Epalinges, Switzerland aut Saugy Martial Laboratoire Suisse d'Analyse du Dopage, Institut Universitaire de Médecine Légale, Ch. des Croisettes 22, 1066, Epalinges, Switzerland aut European Journal of Applied Physiology Springer-Verlag 98/4(2006-11-01), 329-340 1439-6319 98:4<329 2006 98 421 https://doi.org/10.1007/s00421-006-0271-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0271-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Baume Norbert Laboratoire Suisse d'Analyse du Dopage, Institut Universitaire de Médecine Légale, Ch. des Croisettes 22, 1066, Epalinges, Switzerland aut NATIONALLICENCE 700 1- Schumacher Yorck Abtlg. Sportmedizin, Medizinische Universitätsklinik Freiburg, Hugstetter Strasse 55, 79106, Freiburg, Germany aut NATIONALLICENCE 700 1- Sottas Pierre-Edouard Laboratoire Suisse d'Analyse du Dopage, Institut Universitaire de Médecine Légale, Ch. des Croisettes 22, 1066, Epalinges, Switzerland aut NATIONALLICENCE 700 1- Bagutti Carlo Centre Médical Vidy-Med, Rte de Chavannes 11, 1000, Lausanne 23, Switzerland aut NATIONALLICENCE 700 1- Cauderay Michel Hôpital Riviera, Site du Samaritain, Bd. Paderewski 3, 1800, Vevey, Switzerland aut NATIONALLICENCE 700 1- Mangin Patrice Laboratoire Suisse d'Analyse du Dopage, Institut Universitaire de Médecine Légale, Ch. des Croisettes 22, 1066, Epalinges, Switzerland aut NATIONALLICENCE 700 1- Saugy Martial Laboratoire Suisse d'Analyse du Dopage, Institut Universitaire de Médecine Légale, Ch. des Croisettes 22, 1066, Epalinges, Switzerland aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 98/4(2006-11-01), 329-340 1439-6319 98:4<329 2006 98 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 324593988 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer