caa a22 4500 467940304 CHVBK 20180406153010.0 cr unu---uuuuu 170328e20061101xx s 000 0 eng 10.1007/s00421-006-0292-8 doi (NATIONALLICENCE)springer-10.1007/s00421-006-0292-8 Scaling skeletal muscle function to mass in patients with moderate-to-severe COPD [Elektronische Daten] [Carla Malaguti, Luiz Nery, Simone Corso, Lara Nápolis, Marcelo De Fuccio, Marise Castro, J. Alberto Neder] Skeletal muscle performance and muscle mass are commonly reduced in patients with advanced chronic obstructive pulmonary disease (COPD). It is currently unclear, however, whether negative changes in muscle structure and function are proportionately related to each other in these patients. In a cross-sectional study, 39 patients (post-bronchodilator FEV1=49.7±15.5% pred) and 17 controls were submitted to knee isokinetic dynamometry [peak torque (PT), isometric strength (IS), and total work (TW)] and dual energy X-ray absorptiometry for the evaluation of leg muscle mass (LMM). Muscle function (F) was normalised for LMM by using ratio standards (F·LMM−1), power function ratios (F·LMM−b , where b is usually≠1), and analysis of covariance (ANCOVA). Patients with COPD presented with reduced PT, IS, TW, and LMM as compared to controls: there were significant linear correlations among these variables in both groups (P<0.05). Ratio standards of PT·LMM−1 and TW·LMM−1 were, on average, 14% lower in patients than controls (P<0.01). The coefficients for allometric correction of IS and TW were significantly higher in patients as compared to controls (0.975 vs. 0.603 and 1.471 vs. 0.824, respectively, P<0.05), i.e. more LMM was needed to generate a given functional output in patients than normal subjects. In addition, adjusted means of muscle function variables by ANCOVA were 11-18% lower for patients than controls with LMM as the covariate (P<0.05). We conclude that factors other than simple atrophy (i.e. mass-independent mechanisms) might play a role in explaining the COPD-related skeletal muscle dysfunction. Springer-Verlag, 2006 Muscle nationallicence Scaling nationallicence Strength nationallicence COPD nationallicence Oxygen consumption nationallicence Malaguti Carla Pulmonary Function and Clinical Exercise Physiology Unit (SEFICE), Division of Respiratory Diseases, Department of Medicine, Federal University of Sao Paulo (UNIFESP), São Paulo - Paulista School of Medicine (UNIFESP-EPM), Rua Professor Francisco de Castro 54, Vila Clementino, CEP: 04020-050, São Paulo, São Paulo, Brazil aut Nery Luiz Pulmonary Function and Clinical Exercise Physiology Unit (SEFICE), Division of Respiratory Diseases, Department of Medicine, Federal University of Sao Paulo (UNIFESP), São Paulo - Paulista School of Medicine (UNIFESP-EPM), Rua Professor Francisco de Castro 54, Vila Clementino, CEP: 04020-050, São Paulo, São Paulo, Brazil aut Corso Simone Pulmonary Function and Clinical Exercise Physiology Unit (SEFICE), Division of Respiratory Diseases, Department of Medicine, Federal University of Sao Paulo (UNIFESP), São Paulo - Paulista School of Medicine (UNIFESP-EPM), Rua Professor Francisco de Castro 54, Vila Clementino, CEP: 04020-050, São Paulo, São Paulo, Brazil aut Nápolis Lara Pulmonary Function and Clinical Exercise Physiology Unit (SEFICE), Division of Respiratory Diseases, Department of Medicine, Federal University of Sao Paulo (UNIFESP), São Paulo - Paulista School of Medicine (UNIFESP-EPM), Rua Professor Francisco de Castro 54, Vila Clementino, CEP: 04020-050, São Paulo, São Paulo, Brazil aut De Fuccio Marcelo Pulmonary Function and Clinical Exercise Physiology Unit (SEFICE), Division of Respiratory Diseases, Department of Medicine, Federal University of Sao Paulo (UNIFESP), São Paulo - Paulista School of Medicine (UNIFESP-EPM), Rua Professor Francisco de Castro 54, Vila Clementino, CEP: 04020-050, São Paulo, São Paulo, Brazil aut Castro Marise Endocrinology Division, Department of Medicine, Federal University of Sao Paulo (UNIFESP), São Paulo, São Paulo, Brazil aut Alberto Neder J. Pulmonary Function and Clinical Exercise Physiology Unit (SEFICE), Division of Respiratory Diseases, Department of Medicine, Federal University of Sao Paulo (UNIFESP), São Paulo - Paulista School of Medicine (UNIFESP-EPM), Rua Professor Francisco de Castro 54, Vila Clementino, CEP: 04020-050, São Paulo, São Paulo, Brazil aut European Journal of Applied Physiology Springer-Verlag 98/5(2006-11-01), 482-488 1439-6319 98:5<482 2006 98 421 https://doi.org/10.1007/s00421-006-0292-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0292-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Malaguti Carla Pulmonary Function and Clinical Exercise Physiology Unit (SEFICE), Division of Respiratory Diseases, Department of Medicine, Federal University of Sao Paulo (UNIFESP), São Paulo - Paulista School of Medicine (UNIFESP-EPM), Rua Professor Francisco de Castro 54, Vila Clementino, CEP: 04020-050, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Nery Luiz Pulmonary Function and Clinical Exercise Physiology Unit (SEFICE), Division of Respiratory Diseases, Department of Medicine, Federal University of Sao Paulo (UNIFESP), São Paulo - Paulista School of Medicine (UNIFESP-EPM), Rua Professor Francisco de Castro 54, Vila Clementino, CEP: 04020-050, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Corso Simone Pulmonary Function and Clinical Exercise Physiology Unit (SEFICE), Division of Respiratory Diseases, Department of Medicine, Federal University of Sao Paulo (UNIFESP), São Paulo - Paulista School of Medicine (UNIFESP-EPM), Rua Professor Francisco de Castro 54, Vila Clementino, CEP: 04020-050, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Nápolis Lara Pulmonary Function and Clinical Exercise Physiology Unit (SEFICE), Division of Respiratory Diseases, Department of Medicine, Federal University of Sao Paulo (UNIFESP), São Paulo - Paulista School of Medicine (UNIFESP-EPM), Rua Professor Francisco de Castro 54, Vila Clementino, CEP: 04020-050, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- De Fuccio Marcelo Pulmonary Function and Clinical Exercise Physiology Unit (SEFICE), Division of Respiratory Diseases, Department of Medicine, Federal University of Sao Paulo (UNIFESP), São Paulo - Paulista School of Medicine (UNIFESP-EPM), Rua Professor Francisco de Castro 54, Vila Clementino, CEP: 04020-050, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Castro Marise Endocrinology Division, Department of Medicine, Federal University of Sao Paulo (UNIFESP), São Paulo, São Paulo, Brazil aut NATIONALLICENCE 700 1- Alberto Neder J. Pulmonary Function and Clinical Exercise Physiology Unit (SEFICE), Division of Respiratory Diseases, Department of Medicine, Federal University of Sao Paulo (UNIFESP), São Paulo - Paulista School of Medicine (UNIFESP-EPM), Rua Professor Francisco de Castro 54, Vila Clementino, CEP: 04020-050, São Paulo, São Paulo, Brazil aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 98/5(2006-11-01), 482-488 1439-6319 98:5<482 2006 98 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer