caa a22 4500 467940355 CHVBK 20180406153010.0 cr unu---uuuuu 170328e20061101xx s 000 0 eng 10.1007/s00421-006-0293-7 doi (NATIONALLICENCE)springer-10.1007/s00421-006-0293-7 Biomechanical muscle properties and angiotensin-converting enzyme gene polymorphism: a model-based study [Elektronische Daten] [Heiko Wagner, Sigrid Thaller, Regine Dahse, Martin Sust] Previous studies reported an association of angiotensin-converting enzyme (ACE) I/D gene polymorphism with physical performance. The study was based on the hypothesis that certain individual biomechanical muscle properties could be associated with ACE genotype and that they could influence athletes' physical performance. Movement-independent individual biomechanical muscle properties of 62 sports students were determined by applying a mathematical model to experimental data. Subjects exerted concentric and isometric contractions at a leg-press. The model was based on a Hill-type muscle model, a function describing the geometrical arrangement of human leg extensor muscles, and an exponential function describing muscle activation. Mouthwash samples were taken to determine the ACE genotypes. Several combinations of experimentally determined biomechanical properties served as input variables for a discriminant analysis. We were able to show that individual biomechanical muscle properties correlated with ACE I/D gene polymorphism. With a combination of certain individual muscle parameters based on a Hill-type muscle model, we were able to separate three individual ACE genotypes (II, ID, DD) in a significant way (P<0.03) and correctly classify 89% of the cases using a discriminant analysis. We conclude that local biomechanical muscle properties are influenced by ACE genotype. Springer-Verlag, 2006 ACE nationallicence Force velocity nationallicence Biomechanics nationallicence Sport nationallicence Muscle nationallicence Wagner Heiko Institute of Sport Sciences, Biomechanics and Motor Control, University of Muenster, Horstmarer Landweg 62b, 48149, Muenster, Germany aut Thaller Sigrid Institute of Sport Sciences, Karl-Franzens-University Graz, Graz, Austria aut Dahse Regine Institute of Pathology, Helios-Clinic, Erfurt, Germany aut Sust Martin Institute of Sport Sciences, Karl-Franzens-University Graz, Graz, Austria aut European Journal of Applied Physiology Springer-Verlag 98/5(2006-11-01), 507-515 1439-6319 98:5<507 2006 98 421 https://doi.org/10.1007/s00421-006-0293-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0293-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wagner Heiko Institute of Sport Sciences, Biomechanics and Motor Control, University of Muenster, Horstmarer Landweg 62b, 48149, Muenster, Germany aut NATIONALLICENCE 700 1- Thaller Sigrid Institute of Sport Sciences, Karl-Franzens-University Graz, Graz, Austria aut NATIONALLICENCE 700 1- Dahse Regine Institute of Pathology, Helios-Clinic, Erfurt, Germany aut NATIONALLICENCE 700 1- Sust Martin Institute of Sport Sciences, Karl-Franzens-University Graz, Graz, Austria aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 98/5(2006-11-01), 507-515 1439-6319 98:5<507 2006 98 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer