caa a22 4500 467940592 CHVBK 20180406153011.0 cr unu---uuuuu 170328e20060101xx s 000 0 eng 10.1007/s00421-005-0065-9 doi (NATIONALLICENCE)springer-10.1007/s00421-005-0065-9 Living high-training low: tolerance and acclimatization in elite endurance athletes [Elektronische Daten] [Julien V. Brugniaux, Laurent Schmitt, Paul Robach, Hervé Jeanvoine, Hugues Zimmermann, Gérard Nicolet, Alain Duvallet, Jean-Pierre Fouillot, Jean-Paul Richalet] The "living high-training low” (LHTL) model is frequently used to enhance aerobic performance. However, the clinical tolerance and acclimatization process to this intermittent exposure needs to be examined. Forty one athletes from three federations (cross-country skiers, n=11; swimmers, n=18; runners, n=12) separately performed a 13 to 18-day training at the altitude of 1,200m, by sleeping either at 1,200m (CON) or in hypoxic rooms (HYP), with an O2 fraction corresponding to 2,500m (5 nights for swimmers and 6 for skiers and runners), 3,000m (6 nights for skiers, 8 for swimmers and 12 for runners) and 3,500m (6 nights for skiers). Measurements performed before, 1 or 15days after training were ventilatory response (HVRe) and desaturation (ΔSaO2e) during hypoxic exercise, an evaluation of cardiac function by echocardiography, and leukocyte count. Lake Louise AMS score and arterial O2 saturation during sleep were measured daily for HYP. Subjects did not develop symptoms of AMS. Mean nocturnal SaO2 decreased with altitude down to 90% at 3,500m and increased with acclimatization (except at 3,500m). Leukocyte count was not affected except at 3,500m. The heart function was not affected by LHTL. Signs of ventilatory acclimatization were present immediately after training (increased HVRe and decreased ΔSaO2e) and had disappeared 15days later. In conclusion, LHTL was well tolerated and compatible with aerobic training. Comparison of the three patterns of training suggests that a LHTL session should not exceed 3,000m, for at least 18days, with a minimum of 12hday−1 of exposure. Springer-Verlag, 2005 Intermittent hypoxia nationallicence Hypoxic ventilatory response nationallicence Cardiac function nationallicence Leukocyte count nationallicence Nocturnal arterial saturation nationallicence Brugniaux Julien V. Laboratoire "Réponses cellulaires et fonctionnelles à l'hypoxie” EA2363, ARPE, UFR SMBH, Université Paris 13, 74 rue Marcel Cachin, 93017, Bobigny cedex, France aut Schmitt Laurent Laboratoire "Réponses cellulaires et fonctionnelles à l'hypoxie” EA2363, ARPE, UFR SMBH, Université Paris 13, 74 rue Marcel Cachin, 93017, Bobigny cedex, France aut Robach Paul Ecole National de Ski et d'Alpinisme, 74401, Chamonix, France aut Jeanvoine Hervé Hopital de St Claude, 39200, St Claude, France aut Zimmermann Hugues Hôpital de Champagnole, 39300, Champagnole, France aut Nicolet Gérard Centre National de Ski Nordique, 39220, Premanon, France aut Duvallet Alain Laboratoire "Réponses cellulaires et fonctionnelles à l'hypoxie” EA2363, ARPE, UFR SMBH, Université Paris 13, 74 rue Marcel Cachin, 93017, Bobigny cedex, France aut Fouillot Jean-Pierre Laboratoire "Réponses cellulaires et fonctionnelles à l'hypoxie” EA2363, ARPE, UFR SMBH, Université Paris 13, 74 rue Marcel Cachin, 93017, Bobigny cedex, France aut Richalet Jean-Paul Laboratoire "Réponses cellulaires et fonctionnelles à l'hypoxie” EA2363, ARPE, UFR SMBH, Université Paris 13, 74 rue Marcel Cachin, 93017, Bobigny cedex, France aut European Journal of Applied Physiology Springer-Verlag 96/1(2006-01-01), 66-77 1439-6319 96:1<66 2006 96 421 https://doi.org/10.1007/s00421-005-0065-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-005-0065-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brugniaux Julien V. Laboratoire "Réponses cellulaires et fonctionnelles à l'hypoxie” EA2363, ARPE, UFR SMBH, Université Paris 13, 74 rue Marcel Cachin, 93017, Bobigny cedex, France aut NATIONALLICENCE 700 1- Schmitt Laurent Laboratoire "Réponses cellulaires et fonctionnelles à l'hypoxie” EA2363, ARPE, UFR SMBH, Université Paris 13, 74 rue Marcel Cachin, 93017, Bobigny cedex, France aut NATIONALLICENCE 700 1- Robach Paul Ecole National de Ski et d'Alpinisme, 74401, Chamonix, France aut NATIONALLICENCE 700 1- Jeanvoine Hervé Hopital de St Claude, 39200, St Claude, France aut NATIONALLICENCE 700 1- Zimmermann Hugues Hôpital de Champagnole, 39300, Champagnole, France aut NATIONALLICENCE 700 1- Nicolet Gérard Centre National de Ski Nordique, 39220, Premanon, France aut NATIONALLICENCE 700 1- Duvallet Alain Laboratoire "Réponses cellulaires et fonctionnelles à l'hypoxie” EA2363, ARPE, UFR SMBH, Université Paris 13, 74 rue Marcel Cachin, 93017, Bobigny cedex, France aut NATIONALLICENCE 700 1- Fouillot Jean-Pierre Laboratoire "Réponses cellulaires et fonctionnelles à l'hypoxie” EA2363, ARPE, UFR SMBH, Université Paris 13, 74 rue Marcel Cachin, 93017, Bobigny cedex, France aut NATIONALLICENCE 700 1- Richalet Jean-Paul Laboratoire "Réponses cellulaires et fonctionnelles à l'hypoxie” EA2363, ARPE, UFR SMBH, Université Paris 13, 74 rue Marcel Cachin, 93017, Bobigny cedex, France aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 96/1(2006-01-01), 66-77 1439-6319 96:1<66 2006 96 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer