caa a22 4500 467940800 CHVBK 20180406153012.0 cr unu---uuuuu 170328e20060401xx s 000 0 eng 10.1007/s00421-005-0122-4 doi (NATIONALLICENCE)springer-10.1007/s00421-005-0122-4 Adrenomedullin and elements of orthostatic competence after 41h of voluntary submersion in water as measured in four healthy males [Elektronische Daten] [Ingrid Loder, Andreas Rössler, Gert Wurzinger, Roman Duncko, Daniela Jezova, Helmut Hinghofer-Szalkay] Four men established a new score (Guinness Book of Records) by staying submersed in thermoneutral water (average diving depth 2.5m) for 41h without sleeping. The aim of this study is to measure circulating hormones together with plasma mass density and total protein concentration as indices of plasma volume change to test the hypotheses that (1) blood volume and related hormones are influenced by prolonged water submersion the same way as observed after short-term water immersion, and (2) plasma adrenomedullin levels change in an opposite fashion as with orthostatic stimulation. We also studied effects on cortisol and testosterone levels. Water submersion led to a 19% increase in plasma protein concentration and a 2.5g/l rise in plasma mass density, corresponding to a 15.6±1.1% plasma volume decrease (P=0.00). We therefore individually corrected (c) the observed post-submersion hormone values for plasma volume contraction. Based on this correction, we found a rise of plasma adrenomedullin from 7.9±0.9 to 12.5(c)±2.3pg/ml. Aldosterone rose from 123±14 to 186(c)±24ng/ml (P=0.029); plasma renin activity increased in all four persons but the type I error was >0.05. Plasma testosterone decreased from 3.5±0.4 to 2.2(c)±0.6ng/ml (P=0.009) while plasma cortisol stayed unchanged. The daily salivary cortisol rhythm was preserved. We conclude that long-term water submersion has endocrine as well as plasma volume effects that are opposite to those seen after short-term immersion, and which increases plasma adrenomedullin. Circadian cortisol rhythm seems to be conserved even under extreme circumstances as those of this study. Springer-Verlag, 2006 Adrenomedullin nationallicence Volume regulation nationallicence Postural changes nationallicence Plasma renin activity nationallicence Aldosterone nationallicence Loder Ingrid Institute of Adaptive and Spaceflight Physiology, Wormgasse 9, 8010, Graz, Austria aut Rössler Andreas Institute of Systems Physiology, Center of Physiological Medicine, Medical University Graz, Harrachgasse 21, 8010, Graz, Austria aut Wurzinger Gert Department of Pulmology, Medical University, Auenbruggerplatz, 8036, Graz, Austria aut Duncko Roman Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 83306, Bratislava, Slovak Republic aut Jezova Daniela Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 83306, Bratislava, Slovak Republic aut Hinghofer-Szalkay Helmut Institute of Adaptive and Spaceflight Physiology, Wormgasse 9, 8010, Graz, Austria aut European Journal of Applied Physiology Springer-Verlag 96/6(2006-04-01), 644-650 1439-6319 96:6<644 2006 96 421 https://doi.org/10.1007/s00421-005-0122-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-005-0122-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Loder Ingrid Institute of Adaptive and Spaceflight Physiology, Wormgasse 9, 8010, Graz, Austria aut NATIONALLICENCE 700 1- Rössler Andreas Institute of Systems Physiology, Center of Physiological Medicine, Medical University Graz, Harrachgasse 21, 8010, Graz, Austria aut NATIONALLICENCE 700 1- Wurzinger Gert Department of Pulmology, Medical University, Auenbruggerplatz, 8036, Graz, Austria aut NATIONALLICENCE 700 1- Duncko Roman Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 83306, Bratislava, Slovak Republic aut NATIONALLICENCE 700 1- Jezova Daniela Institute of Experimental Endocrinology, Slovak Academy of Sciences, Vlarska 3, 83306, Bratislava, Slovak Republic aut NATIONALLICENCE 700 1- Hinghofer-Szalkay Helmut Institute of Adaptive and Spaceflight Physiology, Wormgasse 9, 8010, Graz, Austria aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 96/6(2006-04-01), 644-650 1439-6319 96:6<644 2006 96 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer