caa a22 4500 467940819 CHVBK 20180406153012.0 cr unu---uuuuu 170328e20060401xx s 000 0 eng 10.1007/s00421-005-0125-1 doi (NATIONALLICENCE)springer-10.1007/s00421-005-0125-1 Diurnal normobaric moderate hypoxia raises serum erythropoietin concentration but does not stimulate accelerated erythrocyte production [Elektronische Daten] [Spencer McLean, Jon Kolb, Stephen Norris, David Smith] This study was performed to examine the effect of diurnal normobaric hypoxia on hematological parameters. Eleven healthy male volunteers were randomly selected to be in either the hypoxic group (n=6) or the control group (n=5). The hypoxic group was exposed to 8h of normobaric hypoxia in hypoxic tent systems that elicited a target peripheral O2 saturation of 81±2% on three consecutive days. The control group spent three consecutive 8-h days in modified tent systems that delivered normoxic air into the tent. Venous blood samples were collected before the exposure (days -5, 0), after each day of the exposure (days 1, 2, 3), and for 3weeks after the exposure (days 7, 10, 13, 17, 24). Serum erythropoietin concentration significantly increased from 9.1±3.3U·L−1 to 30.7±8.6U·L−1 in the hypoxic group. Although there were significant increases in hematocrit (4%), hemoglobin concentration (5%), red blood cell count (4%) on day 7 in the hypoxic group, these observations were likely due to dehydration or biological variation over time. There was no significant change in early erythropoietic markers (reticulocyte counts or serum ferritin concentration), which provided inconclusive evidence of accelerated erythroid differentiation and proliferation. The results suggest that the degree of hypoxia was sufficient to stimulate increased erythropoietin production and release. However, the duration of hypoxic exposure was insufficient to propagate the erythropoietic cascade. Springer-Verlag, 2005 Hypoxia nationallicence Erythropoietin nationallicence Hematology nationallicence Erythropoiesis nationallicence McLean Spencer Human Performance Laboratory, University of Calgary, Calgary, Canada aut Kolb Jon Human Performance Laboratory, University of Calgary, Calgary, Canada aut Norris Stephen Human Performance Laboratory, University of Calgary, Calgary, Canada aut Smith David Human Performance Laboratory, University of Calgary, Calgary, Canada aut European Journal of Applied Physiology Springer-Verlag 96/6(2006-04-01), 651-658 1439-6319 96:6<651 2006 96 421 https://doi.org/10.1007/s00421-005-0125-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-005-0125-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- McLean Spencer Human Performance Laboratory, University of Calgary, Calgary, Canada aut NATIONALLICENCE 700 1- Kolb Jon Human Performance Laboratory, University of Calgary, Calgary, Canada aut NATIONALLICENCE 700 1- Norris Stephen Human Performance Laboratory, University of Calgary, Calgary, Canada aut NATIONALLICENCE 700 1- Smith David Human Performance Laboratory, University of Calgary, Calgary, Canada aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 96/6(2006-04-01), 651-658 1439-6319 96:6<651 2006 96 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer