caa a22 4500 467940827 CHVBK 20180406153012.0 cr unu---uuuuu 170328e20060401xx s 000 0 eng 10.1007/s00421-006-0140-x doi (NATIONALLICENCE)springer-10.1007/s00421-006-0140-x Juel Carsten Copenhagen Muscle Research Centre, Institute of Molecular Biology and Physiology, University of Copenhagen, August Krogh Building, Universitetsparken 13, 2100, Copenhagen, Denmark aut Training-induced changes in membrane transport proteins of human skeletal muscle [Elektronische Daten] [Carsten Juel] Training improves human physical performance by inducing structural and cardiovascular changes, metabolic changes, and changes in the density of membrane transport proteins. This review focuses on the training-induced changes in proteins involved in sarcolemmal membrane transport. It is concluded that the same type of training affects many transport proteins, suggesting that all transport proteins increase with training, and that both sprint and endurance training in humans increase the density of most membrane transport proteins. There seems to be an upper limit for these changes: intense training for 6-8weeks substantially increases the density of membrane proteins, whereas years of training (as performed by athletes) have no further effect. Studies suggest that training-induced changes at the protein level are important functionally. The underlying factors responsible for these changes in transport proteins might include changes in substrate concentration, but the existence of "exercise factors” mediating these responses is more likely. Exercise factors might include Ca2+, mitogen-activated protein kinases, adenosine monophosphate kinases, other kinases, or interleukin-6. Although the magnitudes of training-induced changes have been investigated at the protein level, the underlying signal mechanisms have not been fully described. Springer-Verlag, 2006 Membrane adaptation nationallicence Endurance training nationallicence Sprint training nationallicence European Journal of Applied Physiology Springer-Verlag 96/6(2006-04-01), 627-635 1439-6319 96:6<627 2006 96 421 https://doi.org/10.1007/s00421-006-0140-x text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0140-x text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Juel Carsten Copenhagen Muscle Research Centre, Institute of Molecular Biology and Physiology, University of Copenhagen, August Krogh Building, Universitetsparken 13, 2100, Copenhagen, Denmark aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 96/6(2006-04-01), 627-635 1439-6319 96:6<627 2006 96 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer