caa a22 4500 467940940 CHVBK 20180406153012.0 cr unu---uuuuu 170328e20060201xx s 000 0 eng 10.1007/s00421-005-0078-4 doi (NATIONALLICENCE)springer-10.1007/s00421-005-0078-4 Power output, isometric strength and steadiness in the leg muscles of pre- and postmenopausal women; the effects of hormone replacement therapy [Elektronische Daten] [Serena Carville, Olga Rutherford, Di Newham] There are conflicting reports of the effects of hormone replacement therapy (HRT) on strength preservation in postmenopausal women, while any effect on power output has received little attention. Decreased steadiness of force generation has been reported in older muscles and may be related to the hormonal changes associated with the menopause, but the effect of HRT has not been investigated. We have studied the effect of HRT on strength, power output and isometric force steadiness in healthy women. Sixteen young (aged 27.4±1.4years, mean±SEM) and 29 postmenopausal women were studied. Fifteen of the latter were taking HRT (68.1±1.4years, HRT+) and 14 (70.5±1.5years, HRT−) had never done so. During isometric quadriceps contractions the force steadiness (coefficient of variation of force) was measured at 10, 25, 50 and 100% maximum voluntary contraction (MVC). The average power generated by an explosive leg extension was recorded. The HRT− group generated less power (110.2±7.2W) than both the HRT+ (136.5±10.9W, P=0.027) and young (136.2±5.8W, P=0.027) subjects. Power output was similar in the HRT+ and younger subjects. The HRT− subjects were weaker than the younger ones (241.3±14.0N vs. 297.6±13N, P=0.006). The strength of the HRT+ group (255.5±14N) was not significantly different to the other two groups. There was no difference in steadiness between the three groups at any of the force levels. HRT appears to maintain power output to a greater extent than isometric strength in postmenopausal women. There was no evidence for an effect of either age or HRT on isometric steadiness in the quadriceps. Springer-Verlag, 2005 Ageing nationallicence Skeletal muscle nationallicence Steadiness nationallicence Strength nationallicence Power output nationallicence Hormone replacement therapy nationallicence Carville Serena Division of Applied Biomedical Research School of Biomedical and Health Sciences, King's College London, 3.1 Shepherd's House Guy's Campus, SE1 1UL, London, UK aut Rutherford Olga Division of Applied Biomedical Research School of Biomedical and Health Sciences, King's College London, 3.1 Shepherd's House Guy's Campus, SE1 1UL, London, UK aut Newham Di Division of Applied Biomedical Research School of Biomedical and Health Sciences, King's College London, 3.1 Shepherd's House Guy's Campus, SE1 1UL, London, UK aut European Journal of Applied Physiology Springer-Verlag 96/3(2006-02-01), 292-298 1439-6319 96:3<292 2006 96 421 https://doi.org/10.1007/s00421-005-0078-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-005-0078-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Carville Serena Division of Applied Biomedical Research School of Biomedical and Health Sciences, King's College London, 3.1 Shepherd's House Guy's Campus, SE1 1UL, London, UK aut NATIONALLICENCE 700 1- Rutherford Olga Division of Applied Biomedical Research School of Biomedical and Health Sciences, King's College London, 3.1 Shepherd's House Guy's Campus, SE1 1UL, London, UK aut NATIONALLICENCE 700 1- Newham Di Division of Applied Biomedical Research School of Biomedical and Health Sciences, King's College London, 3.1 Shepherd's House Guy's Campus, SE1 1UL, London, UK aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 96/3(2006-02-01), 292-298 1439-6319 96:3<292 2006 96 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer