caa a22 4500 467941068 CHVBK 20180406153012.0 cr unu---uuuuu 170328e20060301xx s 000 0 eng 10.1007/s00421-005-0089-1 doi (NATIONALLICENCE)springer-10.1007/s00421-005-0089-1 Living high-training low: effect on erythropoiesis and aerobic performance in highly-trained swimmers [Elektronische Daten] [Paul Robach, Laurent Schmitt, Julien Brugniaux, Belle Roels, Grégoire Millet, Philippe Hellard, Gérard Nicolet, Alain Duvallet, Jean-Pierre Fouillot, Stéphane Moutereau, Françoise Lasne, Vincent Pialoux, Niels Olsen, Jean-Paul Richalet] The "living high-training low” model (LHTL), i.e., training in normoxia but sleeping/living in hypoxia, is designed to improve the athletes performance. However, LHTL efficacy still remains controversial and also little is known about the duration of its potential benefit. This study tested whether LHTL enhances aerobic performance in athletes, and if any positive effect may last for up to 2weeks after LHTL intervention. Eighteen swimmers trained for 13days at 1,200m while sleeping/living at 1,200m in ambient air (control, n=9) or in hypoxic rooms (LHTL, n=9, 5days at simulated altitude of 2,500m followed by 8days at simulated altitude of 3,000m, 16hday−1). Measures were done before 1-2days (POST-1) and 2weeks after intervention (POST-15). Aerobic performance was assessed from two swimming trials, exploring $$ \ifmmode\expandafter\dot\else\expandafter\.\fi{V}{\text{O}}_{{2\max }} $$ and endurance performance (2,000-m time trial), respectively. Reticulocyte, serum EPO and soluble transferrin receptor responses were not altered by LHTL, whereas reticulocytes decreased in controls. In POST-1 (vs. before): red blood cell volume increased in LHTL only (+8.5%, P=0.03), $$ \ifmmode\expandafter\dot\else\expandafter\.\fi{V}{\text{O}}_{{2\max }} $$ tended to increase more in LHTL (+8.1%, P=0.09) than in controls (+2.5%, P=0.21) without any difference between groups (P=0.42) and 2,000-m performance was unchanged with LHTL. In POST-15, both performance and hematological parameters were similar to initial levels. Our results indicate that LHTL may stimulate red cell production, without any concurrent amelioration of aerobic performance. The absence of any prolonged benefit after LHTL suggests that this LHTL model cannot be recommended for long-term purposes. Springer-Verlag, 2005 Hypoxia nationallicence Simulated altitude nationallicence Carbon monoxide rebreathing technique nationallicence Training log monitoring nationallicence Ferritin nationallicence Robach Paul Ecole Nationale de Ski et d'Alpinisme, 35, route du Bouchet, 74401, Chamonix, France aut Schmitt Laurent Centre National de Ski Nordique, 39200, Prémanon, France aut Brugniaux Julien Laboratoire "Réponses Cellulaires et Fonctionnelles à l'Hypoxie”, EA2363, ARPE, UFR Médecine, Université Paris 13, 93017, Bobigny, France aut Roels Belle Université de Montpellier 1, EA3759 Approche Bio-Psycho-Sociale du Dopage, 34960, Montpellier, France aut Millet Grégoire Université de Montpellier 1, EA3759 Approche Bio-Psycho-Sociale du Dopage, 34960, Montpellier, France aut Hellard Philippe Fédération Française de Natation, 75980, Paris, France aut Nicolet Gérard Centre National de Ski Nordique, 39200, Prémanon, France aut Duvallet Alain Laboratoire "Réponses Cellulaires et Fonctionnelles à l'Hypoxie”, EA2363, ARPE, UFR Médecine, Université Paris 13, 93017, Bobigny, France aut Fouillot Jean-Pierre Laboratoire "Réponses Cellulaires et Fonctionnelles à l'Hypoxie”, EA2363, ARPE, UFR Médecine, Université Paris 13, 93017, Bobigny, France aut Moutereau Stéphane Laboratoire de Biochimie, Hôpital Henri-Mondor, AP-HP, 94000, Créteil, France aut Lasne Françoise Laboratoire National de Dépistage du Dopage, 92290, Chatenay-Malabry, France aut Pialoux Vincent Laboratoire de Biologie des Activité Physiques et Sportives, Université de Médecine, 63001, Clermont-Ferrand, France aut Olsen Niels Department of Pharmacology, The Panum Institute, University of Copenhagen, 2200, Copenhagen, Denmark aut Richalet Jean-Paul Laboratoire "Réponses Cellulaires et Fonctionnelles à l'Hypoxie”, EA2363, ARPE, UFR Médecine, Université Paris 13, 93017, Bobigny, France aut European Journal of Applied Physiology Springer-Verlag 96/4(2006-03-01), 423-433 1439-6319 96:4<423 2006 96 421 https://doi.org/10.1007/s00421-005-0089-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-005-0089-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Robach Paul Ecole Nationale de Ski et d'Alpinisme, 35, route du Bouchet, 74401, Chamonix, France aut NATIONALLICENCE 700 1- Schmitt Laurent Centre National de Ski Nordique, 39200, Prémanon, France aut NATIONALLICENCE 700 1- Brugniaux Julien Laboratoire "Réponses Cellulaires et Fonctionnelles à l'Hypoxie”, EA2363, ARPE, UFR Médecine, Université Paris 13, 93017, Bobigny, France aut NATIONALLICENCE 700 1- Roels Belle Université de Montpellier 1, EA3759 Approche Bio-Psycho-Sociale du Dopage, 34960, Montpellier, France aut NATIONALLICENCE 700 1- Millet Grégoire Université de Montpellier 1, EA3759 Approche Bio-Psycho-Sociale du Dopage, 34960, Montpellier, France aut NATIONALLICENCE 700 1- Hellard Philippe Fédération Française de Natation, 75980, Paris, France aut NATIONALLICENCE 700 1- Nicolet Gérard Centre National de Ski Nordique, 39200, Prémanon, France aut NATIONALLICENCE 700 1- Duvallet Alain Laboratoire "Réponses Cellulaires et Fonctionnelles à l'Hypoxie”, EA2363, ARPE, UFR Médecine, Université Paris 13, 93017, Bobigny, France aut NATIONALLICENCE 700 1- Fouillot Jean-Pierre Laboratoire "Réponses Cellulaires et Fonctionnelles à l'Hypoxie”, EA2363, ARPE, UFR Médecine, Université Paris 13, 93017, Bobigny, France aut NATIONALLICENCE 700 1- Moutereau Stéphane Laboratoire de Biochimie, Hôpital Henri-Mondor, AP-HP, 94000, Créteil, France aut NATIONALLICENCE 700 1- Lasne Françoise Laboratoire National de Dépistage du Dopage, 92290, Chatenay-Malabry, France aut NATIONALLICENCE 700 1- Pialoux Vincent Laboratoire de Biologie des Activité Physiques et Sportives, Université de Médecine, 63001, Clermont-Ferrand, France aut NATIONALLICENCE 700 1- Olsen Niels Department of Pharmacology, The Panum Institute, University of Copenhagen, 2200, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Richalet Jean-Paul Laboratoire "Réponses Cellulaires et Fonctionnelles à l'Hypoxie”, EA2363, ARPE, UFR Médecine, Université Paris 13, 93017, Bobigny, France aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 96/4(2006-03-01), 423-433 1439-6319 96:4<423 2006 96 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 467941068 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer