caa a22 4500 46794122X CHVBK 20180406153013.0 cr unu---uuuuu 170328e20060301xx s 000 0 eng 10.1007/s00421-005-0098-0 doi (NATIONALLICENCE)springer-10.1007/s00421-005-0098-0 Maximal voluntary hyperpnoea increases blood lactate concentration during exercise [Elektronische Daten] [Michael Johnson, Graham Sharpe, Alison McConnell] Ventilatory work during heavy endurance exercise has not been thought to influence systemic lactate concentration. We evaluated the effect of maximal isocapnic volitional hyperpnoea upon arterialised venous blood lactate concentration ([lac−]B) during leg cycling exercise at maximum lactate steady state (MLSS). Seven healthy males performed a lactate minimum test to estimate MLSS, which was then resolved using separate 30min constant power tests (MLSS=207±8W, mean±SEM). Thereafter, a 30min control trial at MLSS was performed. In a further experimental trial, the control trial was mimicked except that from 20 to 28min maximal isocapnic volitional hyperpnoea was superimposed on exercise. Over 20-28min minute ventilation, oxygen uptake, and heart rate during the control and experimental trials were 87.3±2.4 and 168.3±7.0lmin−1 (P<0.01), the latter being comparable to that achieved in the maximal phase of the lactate minimum test (171.9±6.8lmin−1), 3.46±0.20 and 3.83 ± 0.20lmin−1 (P<0.01), and 158.5±2.7 and 166.8±2.7beatsmin−1 (P<0.05), respectively. From 20 to 30min of the experimental trial [lac−]B increased from 3.7±0.2 to 4.7±0.3mmoll−1 (P<0.05). The partial pressure of carbon dioxide in arterialised venous blood increased approximately 3mmHg during volitional hyperpnoea, which may have attenuated the [lac−]B increase. These results show that, during heavy exercise, respiratory muscle work may affect [lac−]B. We speculate that the changes observed were related to the altered lactate turnover in respiratory muscles, locomotor muscles, or both. Springer-Verlag, 2006 Cycle ergometry nationallicence Maximal exercise nationallicence Respiratory muscle work nationallicence Blood lactate nationallicence Johnson Michael School of Biomedical and Natural Sciences, Nottingham Trent University, NG11 8NS, Nottingham, UK aut Sharpe Graham School of Biomedical and Natural Sciences, Nottingham Trent University, NG11 8NS, Nottingham, UK aut McConnell Alison Sport Sciences, Brunel University, UB8 3PH, Uxbridge, Middlesex, UK aut European Journal of Applied Physiology Springer-Verlag 96/5(2006-03-01), 600-608 1439-6319 96:5<600 2006 96 421 https://doi.org/10.1007/s00421-005-0098-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-005-0098-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Johnson Michael School of Biomedical and Natural Sciences, Nottingham Trent University, NG11 8NS, Nottingham, UK aut NATIONALLICENCE 700 1- Sharpe Graham School of Biomedical and Natural Sciences, Nottingham Trent University, NG11 8NS, Nottingham, UK aut NATIONALLICENCE 700 1- McConnell Alison Sport Sciences, Brunel University, UB8 3PH, Uxbridge, Middlesex, UK aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 96/5(2006-03-01), 600-608 1439-6319 96:5<600 2006 96 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer