caa a22 4500 467941300 CHVBK 20180406153013.0 cr unu---uuuuu 170328e20060301xx s 000 0 eng 10.1007/s00421-005-0114-4 doi (NATIONALLICENCE)springer-10.1007/s00421-005-0114-4 Influence of the menstrual cycle on proenkephalin peptide F responses to maximal cycle exercise [Elektronische Daten] [William Kraemer, Sang Kim, Jill Bush, Bradley Nindl, Jeff Volek, Barry Spiering, Disa Hatfield, Maren Fragala, Margo Putukian, Wayne Sebastianelli] Proenkephalin peptide F [107-140] is an enkephalin-containing peptide found predominantly within the adrenal medulla and is co-packaged with epinephrine within adrenal medullary chromaffin granules. Peptide F has been shown to have the classic opioid analgesia effects along with immune cell interactions. This is only the second peptide F study in women, and in it we compare the responses of peptide F to a maximal cycle exercise test and recovery values over the follicular and luteal phases of the menstrual cycle. Eight untrained (directly documented in this study) women who were eumenorrheic performed a progressive maximal exercise test to volitional exhaustion on a cycle ergometer, once during the follicular phase, and once during the luteal phases of the menstrual cycle. Blood was obtained pre-exercise, immediately post-exercise and at 0, 15, and 30min into recovery. Typical exercise changes in response to the cycle tests were observed with blood lactate increases that remained elevated 30min into recovery. No significant exercise-induced elevations were observed for peptide F concentrations with exercise nor were any differences observed between the two menstrual phases. Thus, the effects of the menstrual cycle on peptide F concentrations appear to be minimal under the conditions of this investigation. With high concentrations of peptide F observed at rest (approx. 0.2-0.3pmolml−1) pre-exercise arousal mechanisms may have obviated any exercise-induced response. In addition, inhibition via elevated epinephrine may have inhibited any post-exercise increases and finally adrenal medullary capacity for circulatory concentrations of peptide F may have been reached in such untrained women. Pre-exercise arousal mechanisms potentially related to analgesia may also be involved to prepare untrained women for the stress of maximal exercise. Springer-Verlag, 2005 Opioid peptides nationallicence Pre-exercise arousal nationallicence Analgesia nationallicence Adrenal medulla nationallicence Kraemer William Human Performance Laboratory, Department of Kinesiology, University of Connecticut, 06269, Storrs, CT, USA aut Kim Sang Center for Sports Medicine, The Pennsylvania State University, 16802, University Park, PA, USA aut Bush Jill Laboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 77204, Houston, TX, USA aut Nindl Bradley Military Performance Division, US Army Research Institute of Environmental Medicine, 01760, Natick, MA, USA aut Volek Jeff Human Performance Laboratory, Department of Kinesiology, University of Connecticut, 06269, Storrs, CT, USA aut Spiering Barry Human Performance Laboratory, Department of Kinesiology, University of Connecticut, 06269, Storrs, CT, USA aut Hatfield Disa Human Performance Laboratory, Department of Kinesiology, University of Connecticut, 06269, Storrs, CT, USA aut Fragala Maren Human Performance Laboratory, Department of Kinesiology, University of Connecticut, 06269, Storrs, CT, USA aut Putukian Margo Sports Medicine, Princeton University, 08544, Princeton, NJ, USA aut Sebastianelli Wayne Center for Sports Medicine, The Pennsylvania State University, 16802, University Park, PA, USA aut European Journal of Applied Physiology Springer-Verlag 96/5(2006-03-01), 581-586 1439-6319 96:5<581 2006 96 421 https://doi.org/10.1007/s00421-005-0114-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-005-0114-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kraemer William Human Performance Laboratory, Department of Kinesiology, University of Connecticut, 06269, Storrs, CT, USA aut NATIONALLICENCE 700 1- Kim Sang Center for Sports Medicine, The Pennsylvania State University, 16802, University Park, PA, USA aut NATIONALLICENCE 700 1- Bush Jill Laboratory of Integrated Physiology, Department of Health and Human Performance, University of Houston, 77204, Houston, TX, USA aut NATIONALLICENCE 700 1- Nindl Bradley Military Performance Division, US Army Research Institute of Environmental Medicine, 01760, Natick, MA, USA aut NATIONALLICENCE 700 1- Volek Jeff Human Performance Laboratory, Department of Kinesiology, University of Connecticut, 06269, Storrs, CT, USA aut NATIONALLICENCE 700 1- Spiering Barry Human Performance Laboratory, Department of Kinesiology, University of Connecticut, 06269, Storrs, CT, USA aut NATIONALLICENCE 700 1- Hatfield Disa Human Performance Laboratory, Department of Kinesiology, University of Connecticut, 06269, Storrs, CT, USA aut NATIONALLICENCE 700 1- Fragala Maren Human Performance Laboratory, Department of Kinesiology, University of Connecticut, 06269, Storrs, CT, USA aut NATIONALLICENCE 700 1- Putukian Margo Sports Medicine, Princeton University, 08544, Princeton, NJ, USA aut NATIONALLICENCE 700 1- Sebastianelli Wayne Center for Sports Medicine, The Pennsylvania State University, 16802, University Park, PA, USA aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 96/5(2006-03-01), 581-586 1439-6319 96:5<581 2006 96 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer