caa a22 4500 467941505 CHVBK 20180406153014.0 cr unu---uuuuu 170328e20060501xx s 000 0 eng 10.1007/s00421-006-0142-8 doi (NATIONALLICENCE)springer-10.1007/s00421-006-0142-8 RAAS polymorphisms alter the acute blood pressure response to aerobic exercise among men with hypertension [Elektronische Daten] [Bruce Blanchard, Gregory Tsongalis, Margaux Guidry, Lisa LaBelle, Michelle Poulin, Amy Taylor, Carl Maresh, Joseph Devaney, Paul Thompson, Linda Pescatello] Limited evidence suggests renin-angiotensin-aldosterone system (RAAS) polymorphisms alter the blood pressure (BP) response to aerobic exercise training. We examined if RAAS polymorphisms influenced postexercise hypotension in men with high normal to Stage 1 hypertension. Forty-seven men (44.2±1.4years, 145.1±1.6/85.5±1.1mmHg) randomly completed three experiments: seated rest (control) and two cycle exercise bouts at 40% (LITE) and 60% (MOD) of maximal oxygen consumption. Ambulating BP was measured for 14h after each experiment. RAAS polymorphisms associated with hypertension (i.e. angiotensin converting I enzyme, ACE I/D; angiotensin II type 1 receptor, AT1R A/C; and intron 2 of aldosterone synthase, Int2 W/C) were analyzed using polymerase chain reaction and restriction enzyme digestion. Repeated measure ANOVA tested if BP differed between experimental conditions by RAAS genotypes. Compared to men with 0-2 variant alleles, men with ≥3 combined RAAS variant alleles had lower average systolic BP (SBP) (P=0.030) and lower average diastolic BP (DBP) (P=0.009) for 14h only after LITE. In contrast, average BP was not different for MOD and control between RAAS variant allele groups over this time period (P≥0.05). LITE reduced BP in men with ≥3 variant RAAS alleles for 14h, whereas MOD had no influence on BP in these men. In order to optimally prescribe exercise for its BP lowering benefits in those with hypertension, additional knowledge of how genetic variation affects the BP response to exercise is needed. Springer-Verlag, 2006 Genetics nationallicence Postexercise hypotension nationallicence Cycle exercise nationallicence Ambulatory blood pressure nationallicence Blanchard Bruce University of CT, Storrs, CT, USA aut Tsongalis Gregory Hartford Hospital, 80 Seymour Street, Bliss 312, 06102, Hartford, CT, USA aut Guidry Margaux University of CT, Storrs, CT, USA aut LaBelle Lisa Hartford Hospital, 80 Seymour Street, Bliss 312, 06102, Hartford, CT, USA aut Poulin Michelle Hartford Hospital, 80 Seymour Street, Bliss 312, 06102, Hartford, CT, USA aut Taylor Amy Hartford Hospital, 80 Seymour Street, Bliss 312, 06102, Hartford, CT, USA aut Maresh Carl University of CT, Storrs, CT, USA aut Devaney Joseph Children's National Medical Center, Washington, DC, USA aut Thompson Paul Hartford Hospital, 80 Seymour Street, Bliss 312, 06102, Hartford, CT, USA aut Pescatello Linda University of CT, Storrs, CT, USA aut European Journal of Applied Physiology Springer-Verlag 97/1(2006-05-01), 26-33 1439-6319 97:1<26 2006 97 421 https://doi.org/10.1007/s00421-006-0142-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0142-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Blanchard Bruce University of CT, Storrs, CT, USA aut NATIONALLICENCE 700 1- Tsongalis Gregory Hartford Hospital, 80 Seymour Street, Bliss 312, 06102, Hartford, CT, USA aut NATIONALLICENCE 700 1- Guidry Margaux University of CT, Storrs, CT, USA aut NATIONALLICENCE 700 1- LaBelle Lisa Hartford Hospital, 80 Seymour Street, Bliss 312, 06102, Hartford, CT, USA aut NATIONALLICENCE 700 1- Poulin Michelle Hartford Hospital, 80 Seymour Street, Bliss 312, 06102, Hartford, CT, USA aut NATIONALLICENCE 700 1- Taylor Amy Hartford Hospital, 80 Seymour Street, Bliss 312, 06102, Hartford, CT, USA aut NATIONALLICENCE 700 1- Maresh Carl University of CT, Storrs, CT, USA aut NATIONALLICENCE 700 1- Devaney Joseph Children's National Medical Center, Washington, DC, USA aut NATIONALLICENCE 700 1- Thompson Paul Hartford Hospital, 80 Seymour Street, Bliss 312, 06102, Hartford, CT, USA aut NATIONALLICENCE 700 1- Pescatello Linda University of CT, Storrs, CT, USA aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 97/1(2006-05-01), 26-33 1439-6319 97:1<26 2006 97 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer