caa a22 4500 467941564 CHVBK 20180406153014.0 cr unu---uuuuu 170328e20060501xx s 000 0 eng 10.1007/s00421-006-0144-6 doi (NATIONALLICENCE)springer-10.1007/s00421-006-0144-6 Time components of circulatory transport from the lungs to a peripheral artery in humans [Elektronische Daten] [P. Lindholm, L. Karlsson, H. Gill, O. Wigertz, D. Linnarsson] Blood gas changes occurring in the lung undergo delay and damping on their way to a peripheral artery sampling site. Knowledge of the time components of circulatory transfer is important for the understanding of respiratory control and cardiovascular reflexes in response to blood gas transients. Providing steady state with regard to $$ {\mathop {\text{V}}\limits^. }_{{\text{A}}} /{\text{\ifmmode\expandafter\dot\else\expandafter\.\fi{Q}}} $$ distribution, cardiac output and peripheral blood flow, the relationship between the time courses of small end-tidal and peripheral PO2 changes is determined by the transfer function of the interposed vascular segment. This transfer function, expressed as delay time T D and mean transit time (MTT), was measured in six well-trained subjects, allowing the calculation of arterial time-courses from end-tidal to the reverse. They were studied at rest and during four different dynamic leg exercise intensities in the supine posture. T D and MTT amounted to 15.8±1.7 (mean±SEM) and 18.3±2.1s at rest and were shortened to 7.7±0.6 and 11.5±1.8s during exercise at 170W. The shortening of T D and MTT did not appear to be simply an inverse function of cardiac output, suggesting that the shortening occurs in the central circulatory segment but not in the arm segment. Springer-Verlag, 2006 Arterial transfer functions nationallicence Blood gases nationallicence Control dynamics nationallicence Deconvolution nationallicence Lindholm P. Department of Physiology and Pharmacology, Section of Environmental Physiology, Karolinska Institutet, 17177, Stockholm, Sweden aut Karlsson L. Department of Physiology and Pharmacology, Section of Environmental Physiology, Karolinska Institutet, 17177, Stockholm, Sweden aut Gill H. Department of Biomedical Engineering, Medical Informatics, Linköping University, Linköping, Sweden aut Wigertz O. Department of Biomedical Engineering, Medical Informatics, Linköping University, Linköping, Sweden aut Linnarsson D. Department of Physiology and Pharmacology, Section of Environmental Physiology, Karolinska Institutet, 17177, Stockholm, Sweden aut European Journal of Applied Physiology Springer-Verlag 97/1(2006-05-01), 96-102 1439-6319 97:1<96 2006 97 421 https://doi.org/10.1007/s00421-006-0144-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0144-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lindholm P. Department of Physiology and Pharmacology, Section of Environmental Physiology, Karolinska Institutet, 17177, Stockholm, Sweden aut NATIONALLICENCE 700 1- Karlsson L. Department of Physiology and Pharmacology, Section of Environmental Physiology, Karolinska Institutet, 17177, Stockholm, Sweden aut NATIONALLICENCE 700 1- Gill H. Department of Biomedical Engineering, Medical Informatics, Linköping University, Linköping, Sweden aut NATIONALLICENCE 700 1- Wigertz O. Department of Biomedical Engineering, Medical Informatics, Linköping University, Linköping, Sweden aut NATIONALLICENCE 700 1- Linnarsson D. Department of Physiology and Pharmacology, Section of Environmental Physiology, Karolinska Institutet, 17177, Stockholm, Sweden aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 97/1(2006-05-01), 96-102 1439-6319 97:1<96 2006 97 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer