caa a22 4500 467941602 CHVBK 20180406153014.0 cr unu---uuuuu 170328e20060501xx s 000 0 eng 10.1007/s00421-006-0154-4 doi (NATIONALLICENCE)springer-10.1007/s00421-006-0154-4 PPARα gene variation and physical performance in Russian athletes [Elektronische Daten] [Ildus I Ahmetov, Irina Mozhayskaya, David Flavell, Irina V Astratenkova, Antonina I Komkova, Ekaterina V Lyubaeva, Pavel Tarakin, Boris Shenkman, Anastasia Vdovina, Aleksei I Netreba, Daniil V Popov, Olga Vinogradova, Hugh Montgomery, Viktor Rogozkin] Peroxisome proliferator-activated receptor α (PPARα) regulates genes responsible for skeletal and heart muscle fatty acid oxidation. Previous studies have shown that the PPARα intron 7 G/C polymorphism was associated with left ventricular growth in response to exercise. We speculated that GG homozygotes should be more prevalent within a group of endurance-oriented athletes, have normal fatty acid metabolism, and increased percentages of slow-twitch fibers. We have tested this hypothesis in the study of a mixed cohort of 786 Russian athletes in 13 different sporting disciplines prospectively stratified by performance (endurance-oriented athletes, power-oriented athletes and athletes with mixed endurance/power activity). PPARα intron 7 genotype and allele frequencies were compared to 1,242 controls. We found an increasing linear trend of C allele with increasing anaerobic component of physical performance (P=0.029). GG genotype frequencies in endurance-oriented and power-oriented athletes were 80.3 and 50.6%, respectively, and were significantly (P<0.0001) different compared to controls (70.0%). To examine the association between PPARα gene variant and fiber type composition, muscle biopsies from m. vastus lateralis were obtained and analyzed in 40 young men. GG homozygotes (n=25) had significantly (P=0.003) higher percentages of slow-twitch fibers (55.5±2.0 vs 38.5±2.3%) than CC homozygotes (n=4). In conclusion, PPARα intron 7 G/C polymorphism was associated with physical performance in Russian athletes, and this may be explained, in part, by the association between PPARα genotype and muscle fiber type composition. Springer-Verlag, 2006 PPARα nationallicence Polymorphism nationallicence Fatty acids nationallicence Muscle fiber type nationallicence Physical performance nationallicence Ahmetov Ildus I. Sports Genetics Laboratory, St Petersburg Research Institute of Physical Culture, 2 Dynamo Street, 197110, St Petersburg, Russia aut Mozhayskaya Irina Sports Genetics Laboratory, St Petersburg Research Institute of Physical Culture, 2 Dynamo Street, 197110, St Petersburg, Russia aut Flavell David Centre for Cardiovascular Genetics, Department of Medicine, Royal Free and University College London Medical School, The Rayne Institute, 5 University Street, WC1E 6JF, London, UK aut Astratenkova Irina V. Sports Genetics Laboratory, St Petersburg Research Institute of Physical Culture, 2 Dynamo Street, 197110, St Petersburg, Russia aut Komkova Antonina I. Sports Genetics Laboratory, St Petersburg Research Institute of Physical Culture, 2 Dynamo Street, 197110, St Petersburg, Russia aut Lyubaeva Ekaterina V. SSC RF Institute for Biomedical Problems, 76A Khoroshevskoe Chaussee, 123007, Moscow, Russia aut Tarakin Pavel SSC RF Institute for Biomedical Problems, 76A Khoroshevskoe Chaussee, 123007, Moscow, Russia aut Shenkman Boris SSC RF Institute for Biomedical Problems, 76A Khoroshevskoe Chaussee, 123007, Moscow, Russia aut Vdovina Anastasia SSC RF Institute for Biomedical Problems, 76A Khoroshevskoe Chaussee, 123007, Moscow, Russia aut Netreba Aleksei I. SSC RF Institute for Biomedical Problems, 76A Khoroshevskoe Chaussee, 123007, Moscow, Russia aut Popov Daniil V. SSC RF Institute for Biomedical Problems, 76A Khoroshevskoe Chaussee, 123007, Moscow, Russia aut Vinogradova Olga SSC RF Institute for Biomedical Problems, 76A Khoroshevskoe Chaussee, 123007, Moscow, Russia aut Montgomery Hugh Institute for Human Health and Performance, University College London, N19 5LW, London, UK aut Rogozkin Viktor Sports Genetics Laboratory, St Petersburg Research Institute of Physical Culture, 2 Dynamo Street, 197110, St Petersburg, Russia aut European Journal of Applied Physiology Springer-Verlag 97/1(2006-05-01), 103-108 1439-6319 97:1<103 2006 97 421 https://doi.org/10.1007/s00421-006-0154-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0154-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ahmetov Ildus I. Sports Genetics Laboratory, St Petersburg Research Institute of Physical Culture, 2 Dynamo Street, 197110, St Petersburg, Russia aut NATIONALLICENCE 700 1- Mozhayskaya Irina Sports Genetics Laboratory, St Petersburg Research Institute of Physical Culture, 2 Dynamo Street, 197110, St Petersburg, Russia aut NATIONALLICENCE 700 1- Flavell David Centre for Cardiovascular Genetics, Department of Medicine, Royal Free and University College London Medical School, The Rayne Institute, 5 University Street, WC1E 6JF, London, UK aut NATIONALLICENCE 700 1- Astratenkova Irina V. Sports Genetics Laboratory, St Petersburg Research Institute of Physical Culture, 2 Dynamo Street, 197110, St Petersburg, Russia aut NATIONALLICENCE 700 1- Komkova Antonina I. Sports Genetics Laboratory, St Petersburg Research Institute of Physical Culture, 2 Dynamo Street, 197110, St Petersburg, Russia aut NATIONALLICENCE 700 1- Lyubaeva Ekaterina V. SSC RF Institute for Biomedical Problems, 76A Khoroshevskoe Chaussee, 123007, Moscow, Russia aut NATIONALLICENCE 700 1- Tarakin Pavel SSC RF Institute for Biomedical Problems, 76A Khoroshevskoe Chaussee, 123007, Moscow, Russia aut NATIONALLICENCE 700 1- Shenkman Boris SSC RF Institute for Biomedical Problems, 76A Khoroshevskoe Chaussee, 123007, Moscow, Russia aut NATIONALLICENCE 700 1- Vdovina Anastasia SSC RF Institute for Biomedical Problems, 76A Khoroshevskoe Chaussee, 123007, Moscow, Russia aut NATIONALLICENCE 700 1- Netreba Aleksei I. SSC RF Institute for Biomedical Problems, 76A Khoroshevskoe Chaussee, 123007, Moscow, Russia aut NATIONALLICENCE 700 1- Popov Daniil V. SSC RF Institute for Biomedical Problems, 76A Khoroshevskoe Chaussee, 123007, Moscow, Russia aut NATIONALLICENCE 700 1- Vinogradova Olga SSC RF Institute for Biomedical Problems, 76A Khoroshevskoe Chaussee, 123007, Moscow, Russia aut NATIONALLICENCE 700 1- Montgomery Hugh Institute for Human Health and Performance, University College London, N19 5LW, London, UK aut NATIONALLICENCE 700 1- Rogozkin Viktor Sports Genetics Laboratory, St Petersburg Research Institute of Physical Culture, 2 Dynamo Street, 197110, St Petersburg, Russia aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 97/1(2006-05-01), 103-108 1439-6319 97:1<103 2006 97 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer