caa a22 4500 467941769 CHVBK 20180406153014.0 cr unu---uuuuu 170328e20060801xx s 000 0 eng 10.1007/s00421-006-0240-7 doi (NATIONALLICENCE)springer-10.1007/s00421-006-0240-7 Living high-training low: effect on erythropoiesis and maximal aerobic performance in elite Nordic skiers [Elektronische Daten] [Paul Robach, Laurent Schmitt, Julien Brugniaux, Gérard Nicolet, Alain Duvallet, Jean-Pierre Fouillot, Stéphane Moutereau, Françoise Lasne, Vincent Pialoux, Niels Olsen, Jean-Paul Richalet] The "living high-training low” model (Hi-Lo) may improve aerobic performance in athletes, and the main mechanism of this improvement is thought to be augmented erythropoiesis. A positive effect of Hi-Lo has been demonstrated previously by using altitudes of 2,000-3,000m. Since the rate of erythropoiesis is altitude-dependent, we tested whether a higher altitude (3,500m) during Hi-Lo increases erythropoiesis and maximal aerobic performance. Nordic skiers trained for 18days at 1,200m, while sleeping at 1,200m in ambient air (control group, n=5) or in hypoxic rooms (Hi-Lo, n=6; 3×6days at simulated altitudes of 2,500, 3,000 and finally 3,500m, 11hday−1). Measurements were done before, during (blood samples only) and 2weeks after the intervention (POST). Maximal aerobic performance was examined from $$\dot{V}\hbox{O}_{2}\hbox{max}$$ and time to exhaustion (T exh) at $$v\dot{V}\hbox{O}_{2}\hbox{max}$$ (minimum speed associated with $$\dot{V}\hbox{O}_{2}\hbox{max}$$ ), respectively. Erythropoietin and soluble transferrin receptor responses were higher during Hi-Lo, whereas reticulocytes did not change. In POST (vs. before): hematological parameters were similar to basal levels, as well as red blood cell volume, being 2.68±0.83l (vs. 2.64±0.54l) in Hi-Lo and 2.62±0.57l (vs. 2.87±0.59l) in controls. At that time, neither $$\dot{V}\hbox{O}_{2}\hbox{max}$$ nor T exh were improved by Hi-Lo, $$\dot{V}\hbox{O}_{2}\hbox{max}$$ being non-significantly decreased by 2.0% (controls) and 3.7% (Hi-Lo). The present results suggest that increasing the altitude up to 3,500m during Hi-Lo stimulates erythropoiesis but does not confer any advantage for maximal O2 transport. Springer-Verlag, 2006 Hypoxia nationallicence Maximal oxygen uptake nationallicence Cross-country ski nationallicence Biathlon nationallicence Robach Paul Ecole Nationale de Ski et d'Alpinisme, 35, route du Bouchet, 74401, Chamonix, France aut Schmitt Laurent Centre National de Ski Nordique, 39220, Prémanon, France aut Brugniaux Julien UFR Médecine, Laboratoire "Réponses Cellulaires et Fonctionnelles à l'Hypoxie”, Université Paris 13, EA2363, ARPE, 93017, Bobigny, France aut Nicolet Gérard Centre National de Ski Nordique, 39220, Prémanon, France aut Duvallet Alain UFR Médecine, Laboratoire "Réponses Cellulaires et Fonctionnelles à l'Hypoxie”, Université Paris 13, EA2363, ARPE, 93017, Bobigny, France aut Fouillot Jean-Pierre UFR Médecine, Laboratoire "Réponses Cellulaires et Fonctionnelles à l'Hypoxie”, Université Paris 13, EA2363, ARPE, 93017, Bobigny, France aut Moutereau Stéphane Hôpital Henri-Mondor, Laboratoire de Biochimie, AP-HP, 94000, Créteil, France aut Lasne Françoise Laboratoire National de Dépistage du Dopage, 92290, Chatenay-Malabry, France aut Pialoux Vincent Laboratoire de Biologie des Activités Physiques et Sportives, Université Clermont 1, Clermont-Ferrand, France aut Olsen Niels Institute of Neurobiology and Molecular Pharmacology, University of Copenhagen, 2200, Copenhagen, Denmark aut Richalet Jean-Paul UFR Médecine, Laboratoire "Réponses Cellulaires et Fonctionnelles à l'Hypoxie”, Université Paris 13, EA2363, ARPE, 93017, Bobigny, France aut European Journal of Applied Physiology Springer-Verlag 97/6(2006-08-01), 695-705 1439-6319 97:6<695 2006 97 421 https://doi.org/10.1007/s00421-006-0240-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0240-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Robach Paul Ecole Nationale de Ski et d'Alpinisme, 35, route du Bouchet, 74401, Chamonix, France aut NATIONALLICENCE 700 1- Schmitt Laurent Centre National de Ski Nordique, 39220, Prémanon, France aut NATIONALLICENCE 700 1- Brugniaux Julien UFR Médecine, Laboratoire "Réponses Cellulaires et Fonctionnelles à l'Hypoxie”, Université Paris 13, EA2363, ARPE, 93017, Bobigny, France aut NATIONALLICENCE 700 1- Nicolet Gérard Centre National de Ski Nordique, 39220, Prémanon, France aut NATIONALLICENCE 700 1- Duvallet Alain UFR Médecine, Laboratoire "Réponses Cellulaires et Fonctionnelles à l'Hypoxie”, Université Paris 13, EA2363, ARPE, 93017, Bobigny, France aut NATIONALLICENCE 700 1- Fouillot Jean-Pierre UFR Médecine, Laboratoire "Réponses Cellulaires et Fonctionnelles à l'Hypoxie”, Université Paris 13, EA2363, ARPE, 93017, Bobigny, France aut NATIONALLICENCE 700 1- Moutereau Stéphane Hôpital Henri-Mondor, Laboratoire de Biochimie, AP-HP, 94000, Créteil, France aut NATIONALLICENCE 700 1- Lasne Françoise Laboratoire National de Dépistage du Dopage, 92290, Chatenay-Malabry, France aut NATIONALLICENCE 700 1- Pialoux Vincent Laboratoire de Biologie des Activités Physiques et Sportives, Université Clermont 1, Clermont-Ferrand, France aut NATIONALLICENCE 700 1- Olsen Niels Institute of Neurobiology and Molecular Pharmacology, University of Copenhagen, 2200, Copenhagen, Denmark aut NATIONALLICENCE 700 1- Richalet Jean-Paul UFR Médecine, Laboratoire "Réponses Cellulaires et Fonctionnelles à l'Hypoxie”, Université Paris 13, EA2363, ARPE, 93017, Bobigny, France aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 97/6(2006-08-01), 695-705 1439-6319 97:6<695 2006 97 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 467941068 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer