caa a22 4500 467941777 CHVBK 20180406153015.0 cr unu---uuuuu 170328e20060801xx s 000 0 eng 10.1007/s00421-006-0230-9 doi (NATIONALLICENCE)springer-10.1007/s00421-006-0230-9 Plasma Hsp72 is higher in runners with more serious symptoms of exertional heat illness [Elektronische Daten] [P. Ruell, M. Thompson, K. Hoffman, J. Brotherhood, D. Richards] Exertional heat illness is a potentially fatal disorder that primarily affects fit young men. Plasma Hsp72 may be important in the aetiology of this disorder, acting as a danger signal to the organism and leading to an inflammatory response. The aim of this study was to determine whether patients with exertional heat illness following a 14km run show a difference in their plasma Hsp72 concentration compared with control subjects who completed the event without incident. Patients (n=22) and controls (n=7) were all male. The patients were subdivided into two groups, one of which exhibited more serious symptoms indicating neurological impairment such as confusion (n=13) (CNS) while the other group exhibited mild symptoms (MILD) (n=9). The CNS group had a higher rectal temperature (T rec) compared with the control group (41.0±0.3 vs. 39.8±0.2°C, P<0.05, mean±SE). Immediately after the run plasma Hsp72 was higher in the CNS group compared to controls and patients with mild symptoms (37.9, 17.0, and 20.9ng/ml, respectively, P<0.005). There was a correlation between plasma Hsp72 and Trec measured immediately after the race (r=0.597, P<0.001, n=29). However, core temperature was not the only factor leading to increased plasma Hsp72 immediately post race. Plasma Hsp72 was still higher in CNS patients compared with the control group (P<0.05) when T rec was included as a covariate. In conclusion, plasma Hsp72 was elevated immediately after a 14km run with higher levels in patients with more serious symptoms of heat illness. Springer-Verlag, 2006 Exercise nationallicence Heat shock protein nationallicence Heatstroke nationallicence Plasma nationallicence Temperature nationallicence Ruell P. School of Exercise and Sport Science, The University of Sydney, P.O. Box 170, 1825, Lidcombe, NSW, Australia aut Thompson M. School of Exercise and Sport Science, The University of Sydney, P.O. Box 170, 1825, Lidcombe, NSW, Australia aut Hoffman K. School of Exercise and Sport Science, The University of Sydney, P.O. Box 170, 1825, Lidcombe, NSW, Australia aut Brotherhood J. School of Exercise and Sport Science, The University of Sydney, P.O. Box 170, 1825, Lidcombe, NSW, Australia aut Richards D. Sun-Herald City to Surf c/- 1/14 Mons Road, 2145, Westmead, NSW, Australia aut European Journal of Applied Physiology Springer-Verlag 97/6(2006-08-01), 732-736 1439-6319 97:6<732 2006 97 421 https://doi.org/10.1007/s00421-006-0230-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0230-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ruell P. School of Exercise and Sport Science, The University of Sydney, P.O. Box 170, 1825, Lidcombe, NSW, Australia aut NATIONALLICENCE 700 1- Thompson M. School of Exercise and Sport Science, The University of Sydney, P.O. Box 170, 1825, Lidcombe, NSW, Australia aut NATIONALLICENCE 700 1- Hoffman K. School of Exercise and Sport Science, The University of Sydney, P.O. Box 170, 1825, Lidcombe, NSW, Australia aut NATIONALLICENCE 700 1- Brotherhood J. School of Exercise and Sport Science, The University of Sydney, P.O. Box 170, 1825, Lidcombe, NSW, Australia aut NATIONALLICENCE 700 1- Richards D. Sun-Herald City to Surf c/- 1/14 Mons Road, 2145, Westmead, NSW, Australia aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 97/6(2006-08-01), 732-736 1439-6319 97:6<732 2006 97 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer