caa a22 4500 467941823 CHVBK 20180406153015.0 cr unu---uuuuu 170328e20060601xx s 000 0 eng 10.1007/s00421-006-0200-2 doi (NATIONALLICENCE)springer-10.1007/s00421-006-0200-2 Arterioles' contribution to oxygen supply to the skeletal muscles at rest [Elektronische Daten] [Masahiro Shibata, Shigeru Ichioka, Tatsuo Togawa, Akira Kamiya] We tested the hypothesis that oxygen is supplied to the resting skeletal muscle by arterioles rather than by capillaries. This hypothesis was evaluated in rats and rabbits by combining different approaches (1) determination of the intravascular oxygen tension (PO2) in arterioles of different diameters, (2) measurement of the perfused capillary number in response to changes in tissue PO2, and (3) estimation of the optimum capillary number to provide oxygen efficiently to the surrounding tissue. The intravascular PO2 values of arterioles along the vessels decreased downstream, suggesting that a significant amount of oxygen diffuses from the arterioles to the surrounding tissue. The perfused capillary number decreased as the tissue PO2 level was elevated, and this mutual relationship displayed a nonlinear correlation. The results suggest that a boundary PO2 level affecting the capillary recruitment exists for tissue PO2 of less than 40mmHg with the capillary blood-flow stops above that PO2 level. At a high PO2 level, therefore, the oxygen is supplied from the arterioles. Furthermore, an estimation of optimum capillary number reveals that the capillary arrangement is constructed to achieve sufficient oxygen supply to the muscle during exercise, rather than at rest. These results suggest that oxygen is supplied from arterioles to the resting skeletal muscle, whereas the oxygen is supplied from the capillaries during exercise. Springer-Verlag, 2006 Krogh model nationallicence Oxygen transport nationallicence Arterioles nationallicence Vascular walls nationallicence Skeletal muscle nationallicence Shibata Masahiro Department of Biomedical Engineering, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan aut Ichioka Shigeru Department of Biomedical Engineering, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan aut Togawa Tatsuo School of Human Science, Waseda University, 359-1192, Tokorozawa, Saitama, Japan aut Kamiya Akira Department of Biomedical Engineering, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan aut European Journal of Applied Physiology Springer-Verlag 97/3(2006-06-01), 327-331 1439-6319 97:3<327 2006 97 421 https://doi.org/10.1007/s00421-006-0200-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0200-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shibata Masahiro Department of Biomedical Engineering, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan aut NATIONALLICENCE 700 1- Ichioka Shigeru Department of Biomedical Engineering, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan aut NATIONALLICENCE 700 1- Togawa Tatsuo School of Human Science, Waseda University, 359-1192, Tokorozawa, Saitama, Japan aut NATIONALLICENCE 700 1- Kamiya Akira Department of Biomedical Engineering, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-0033, Tokyo, Japan aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 97/3(2006-06-01), 327-331 1439-6319 97:3<327 2006 97 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer