caa a22 4500 467941912 CHVBK 20180406153015.0 cr unu---uuuuu 170328e20060601xx s 000 0 eng 10.1007/s00421-006-0190-0 doi (NATIONALLICENCE)springer-10.1007/s00421-006-0190-0 Supplementation with omega-3 polyunsaturated fatty acids augments brachial artery dilation and blood flow during forearm contraction [Elektronische Daten] [Buddy Walser, Rose Giordano, Charles Stebbins] Omega-3 polyunsaturated fatty acids such as docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) have beneficial effects on the heart and vasculature. We tested the hypothesis that 6weeks of dietary supplementation with DHA (2.0g/day) and EPA (3.0g/day) enhances exercise-induced increases in brachial artery diameter and blood flow during rhythmic exercise. In seven healthy subjects, blood pressure, heart rate and brachial artery diameter, blood flow, and conductance were assessed before and during the last 30s of 90s of rhythmic handgrip exercise (30% of maximal handgrip tension). Blood pressure (MAP), heart rate (HR), and brachial artery vascular conductance were also determined. This paradigm was also performed in six other healthy subjects who received 6weeks of placebo (safflower oil). Placebo treatment had no effect on any variable. DHA and EPA supplementation enhanced contraction-induced increases in brachial artery diameter (0.28±0.04 vs. 0.14±0.03mm), blood flow (367±65 vs. 293±55mlmin−1) and conductance (3.86±0.71 vs. 2.89±0.61mlmin−1mmHg−1) (P<0.05). MAP and HR were unchanged. Results indicate that treatment with DHA and EPA enhances brachial artery blood flow and conductance during exercise. These findings may have implications for individuals with cardiovascular disease and exercise intolerance (e.g., heart failure) Springer-Verlag, 2006 Docosahexaenoic acid nationallicence Eicosapentaenoic acid nationallicence Brachial artery blood flow nationallicence Brachial artery conductance nationallicence Brachial artery dilation nationallicence Exercise nationallicence Walser Buddy Department of Internal Medicine, Division of Cardiovascular Medicine, TB 172, University of California, 95616-8634, Davis, CA, USA aut Giordano Rose Department of Internal Medicine, Division of Cardiovascular Medicine, TB 172, University of California, 95616-8634, Davis, CA, USA aut Stebbins Charles Department of Internal Medicine, Division of Cardiovascular Medicine, TB 172, University of California, 95616-8634, Davis, CA, USA aut European Journal of Applied Physiology Springer-Verlag 97/3(2006-06-01), 347-354 1439-6319 97:3<347 2006 97 421 https://doi.org/10.1007/s00421-006-0190-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0190-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Walser Buddy Department of Internal Medicine, Division of Cardiovascular Medicine, TB 172, University of California, 95616-8634, Davis, CA, USA aut NATIONALLICENCE 700 1- Giordano Rose Department of Internal Medicine, Division of Cardiovascular Medicine, TB 172, University of California, 95616-8634, Davis, CA, USA aut NATIONALLICENCE 700 1- Stebbins Charles Department of Internal Medicine, Division of Cardiovascular Medicine, TB 172, University of California, 95616-8634, Davis, CA, USA aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 97/3(2006-06-01), 347-354 1439-6319 97:3<347 2006 97 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer