caa a22 4500 467941963 CHVBK 20180406153015.0 cr unu---uuuuu 170328e20060601xx s 000 0 eng 10.1007/s00421-006-0160-6 doi (NATIONALLICENCE)springer-10.1007/s00421-006-0160-6 Human skeletal muscle structure and function preserved by vibration muscle exercise following 55days of bed rest [Elektronische Daten] [Dieter Blottner, Michele Salanova, Britta Püttmann, Gudrun Schiffl, Dieter Felsenberg, Björn Buehring, Jörn Rittweger] Prolonged immobilization of the human body results in functional impairments and musculoskeletal system deconditioning that may be attenuated by adequate muscle exercise. In a 56-day horizontal bed rest campaign involving voluntary males we investigated the effects of vibration muscle exercise (RVE, 2×6min daily) on the lower limb skeletal muscles using a newly designed foot plantar trainer (Galileo Space) for use at supine position during bed rest. The maximally voluntary isometric plantar flexion force was maintained following regular RVE bouts during bed rest (controls −18.6 %, P<0.05). At the start (BR2) and end of bed rest (BR55) muscle biopsies were taken from both mixed fast/slow-type vastus lateralis (VL) and mainly slow-type soleus muscle (SOL), each having n=10. RVE group: the size of myofiber types I and II was largely unchanged in VL, and increased in SOL. Ctrl group: the SOL depicted a disrupted pattern of myofibers I/II profiles (i.e., type II>140 % vs. preBR) suggesting a slow-to-fast muscle phenotype shift. In RVE-trained SOL, however, an overall conserved myofiber I/II pattern was documented. RVE training increased the activity-dependent expression of nitric oxide synthase type 1 immunofluorescence at SOL and VL myofiber membranes. These data provide evidence for the beneficial effects of RVE training on the deconditioned structure and function of the lower limb skeletal muscle. Daily short RVE should be employed as an effective atrophy countermeasure co-protocol preferentially addressing postural calf muscles during prolonged clinical immobilization or long-term human space missions. Springer-Verlag, 2006 Skeletal muscle atrophy nationallicence Neuromuscular disorders nationallicence Countermeasure nationallicence Rehabilitation nationallicence Spaceflight nationallicence Blottner Dieter Department of Vegetative Anatomy, Center of Space Medicine Berlin, Neuromuscular Group, Charité University Medicine Berlin, Campus Benjamin Franklin, Arnimallee 22, 14195, Berlin, Germany aut Salanova Michele Department of Vegetative Anatomy, Center of Space Medicine Berlin, Neuromuscular Group, Charité University Medicine Berlin, Campus Benjamin Franklin, Arnimallee 22, 14195, Berlin, Germany aut Püttmann Britta Department of Vegetative Anatomy, Center of Space Medicine Berlin, Neuromuscular Group, Charité University Medicine Berlin, Campus Benjamin Franklin, Arnimallee 22, 14195, Berlin, Germany aut Schiffl Gudrun Department of Vegetative Anatomy, Center of Space Medicine Berlin, Neuromuscular Group, Charité University Medicine Berlin, Campus Benjamin Franklin, Arnimallee 22, 14195, Berlin, Germany aut Felsenberg Dieter Center for Muscle and Bone Research (ZMK), Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, 12200, Berlin, Germany aut Buehring Björn Center for Muscle and Bone Research (ZMK), Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, 12200, Berlin, Germany aut Rittweger Jörn Institute for Biophysical and Clinical Research into Human Movement, Manchester Metropolitan University, ST7 2QL, Alsager, UK aut European Journal of Applied Physiology Springer-Verlag 97/3(2006-06-01), 261-271 1439-6319 97:3<261 2006 97 421 https://doi.org/10.1007/s00421-006-0160-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0160-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Blottner Dieter Department of Vegetative Anatomy, Center of Space Medicine Berlin, Neuromuscular Group, Charité University Medicine Berlin, Campus Benjamin Franklin, Arnimallee 22, 14195, Berlin, Germany aut NATIONALLICENCE 700 1- Salanova Michele Department of Vegetative Anatomy, Center of Space Medicine Berlin, Neuromuscular Group, Charité University Medicine Berlin, Campus Benjamin Franklin, Arnimallee 22, 14195, Berlin, Germany aut NATIONALLICENCE 700 1- Püttmann Britta Department of Vegetative Anatomy, Center of Space Medicine Berlin, Neuromuscular Group, Charité University Medicine Berlin, Campus Benjamin Franklin, Arnimallee 22, 14195, Berlin, Germany aut NATIONALLICENCE 700 1- Schiffl Gudrun Department of Vegetative Anatomy, Center of Space Medicine Berlin, Neuromuscular Group, Charité University Medicine Berlin, Campus Benjamin Franklin, Arnimallee 22, 14195, Berlin, Germany aut NATIONALLICENCE 700 1- Felsenberg Dieter Center for Muscle and Bone Research (ZMK), Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, 12200, Berlin, Germany aut NATIONALLICENCE 700 1- Buehring Björn Center for Muscle and Bone Research (ZMK), Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, 12200, Berlin, Germany aut NATIONALLICENCE 700 1- Rittweger Jörn Institute for Biophysical and Clinical Research into Human Movement, Manchester Metropolitan University, ST7 2QL, Alsager, UK aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 97/3(2006-06-01), 261-271 1439-6319 97:3<261 2006 97 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer