caa a22 4500 46794203X CHVBK 20180406153015.0 cr unu---uuuuu 170328e20060701xx s 000 0 eng 10.1007/s00421-006-0194-9 doi (NATIONALLICENCE)springer-10.1007/s00421-006-0194-9 Acute resistance exercise does not change the hormonal response to sublingual androstenediol intake [Elektronische Daten] [Gregory Brown, Drew McKenzie] Sublingual intake of 21.4mg androstenediol increases serum testosterone concentrations whereas swallowing 200mg androstenediol does not. The duration of increase in serum testosterone following sublingual androstenediol (SL-DIOL) is unknown. Resistance exercise (EX) following SL-DIOL may cause larger increases in serum estradiol concentrations than while at rest. This project evaluated the duration of change in, and the effects of acute EX on, the hormonal response to SL-DIOL. Six young resistance trained males consumed either placebo (PL) or SL-DIOL before a single session of EX or no exercise (Rest) in a random, double blind, crossover manner (for a total of four trials). Blood samples were collected before supplementation, and at 60, 120, 180, 240, 480, and 720min post-supplementation, with the exercise occurring between 60 and 120min. The serum [total testosterone] increased (P<0.05) at 60min similarly in SL-DIOL-EX and SL-DIOL-Rest by ∼115%, and at 120min by ∼107% with no differences due to exercise. The serum [estradiol] increased (P<0.05) similarly in SL-DIOL-EX and SL-DIOL-Rest by ∼33% at 60min and ∼45% at 120min, with no differences due to exercise. Serum [testosterone] returned to baseline by 240min and serum [estradiol] returned to baseline by 720min post-intake. These findings indicate that SL-DIOL acutely elevates serum testosterone and estradiol concentrations, that EX does not alter the endocrine response to SL-DIOL, and that the increases in serum estradiol last between 480 and 720min while the increases in serum testosterone last<240min following acute SL-DIOL intake. Springer-Verlag, 2006 Androstenediol nationallicence Testosterone nationallicence Estradiol nationallicence Androstenedione nationallicence Resistance exercise nationallicence Brown Gregory HPERLS Department, Human Performance Laboratory, The University of Nebraska at Kearney, 68849, Kearney, NE, USA aut McKenzie Drew Jiann-Ping Hsu School of Public Health, Georgia Southern University, 30460, Statesboro, GA, USA aut European Journal of Applied Physiology Springer-Verlag 97/4(2006-07-01), 404-412 1439-6319 97:4<404 2006 97 421 https://doi.org/10.1007/s00421-006-0194-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0194-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brown Gregory HPERLS Department, Human Performance Laboratory, The University of Nebraska at Kearney, 68849, Kearney, NE, USA aut NATIONALLICENCE 700 1- McKenzie Drew Jiann-Ping Hsu School of Public Health, Georgia Southern University, 30460, Statesboro, GA, USA aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 97/4(2006-07-01), 404-412 1439-6319 97:4<404 2006 97 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer