caa a22 4500 467942102 CHVBK 20180406153016.0 cr unu---uuuuu 170328e20060701xx s 000 0 eng 10.1007/s00421-006-0196-7 doi (NATIONALLICENCE)springer-10.1007/s00421-006-0196-7 The effect of 2weeks vitamin C supplementation on immunoendocrine responses to 2.5h cycling exercise in man [Elektronische Daten] [Glen Davison, Michael Gleeson] An increased systemic concentration of stress hormones (of the hypothalamic-pituitary adrenal axis) and some cytokines may contribute to the depression of immune cell function typically observed after prolonged exercise. The aim of the present study was to determine the effect of 2weeks of supplementation with vitamin C (VC) on cortisol, adrenocorticotrophic hormone, interleukin-6, oxidative stress and neutrophil responses to a single bout of endurance exercise. Nine healthy endurance-trained males exercised for 2.5h at 60% $$\dot{V}\hbox{O}_{2{\rm max}}$$ after 2weeks of placebo (PLA) or VC (1,000mgday−1) supplementation. All participants completed both trials utilising a randomised crossover design with a minimum 14day washout period between trials. There was a significant trial×time interaction effect for plasma cortisol concentration (P=0.039) which tended to be lower in the VC trial but post hoc analysis found no specific between trial differences. There was a significantly lower post-exercise neutrophilia (P<0.014) in the VC trial, compared with the PLA trial. There was no trial×time interaction for measures of neutrophil function (bacteria-stimulated elastase release, fMLP or PMA-stimulated oxidative burst). However, there was a trend for higher fMLP-stimulated neutrophil oxidative burst in the VC compared with PLA trial (trial×time interaction, P=0.075). These results suggest that supplementation with VC for a period of up to 2weeks provides little to no protection against the depression of neutrophil function which typically occurs after endurance exercise. Springer-Verlag, 2006 Ascorbate nationallicence Neutrophil nationallicence Stress hormone nationallicence Cytokine nationallicence Oxidative burst nationallicence Davison Glen School of Sport and Exercise Sciences, Loughborough University, LE11 3TU, Loughborough, Leicestershire, UK aut Gleeson Michael School of Sport and Exercise Sciences, Loughborough University, LE11 3TU, Loughborough, Leicestershire, UK aut European Journal of Applied Physiology Springer-Verlag 97/4(2006-07-01), 454-461 1439-6319 97:4<454 2006 97 421 https://doi.org/10.1007/s00421-006-0196-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0196-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Davison Glen School of Sport and Exercise Sciences, Loughborough University, LE11 3TU, Loughborough, Leicestershire, UK aut NATIONALLICENCE 700 1- Gleeson Michael School of Sport and Exercise Sciences, Loughborough University, LE11 3TU, Loughborough, Leicestershire, UK aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 97/4(2006-07-01), 454-461 1439-6319 97:4<454 2006 97 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer