caa a22 4500 467942129 CHVBK 20180406153016.0 cr unu---uuuuu 170328e20060701xx s 000 0 eng 10.1007/s00421-006-0191-z doi (NATIONALLICENCE)springer-10.1007/s00421-006-0191-z Hyperhydration prior to a simulated second day of the 3-day moderate intensity equestrian competition does not cause arterial hypoxemia in Thoroughbred horses [Elektronische Daten] [B. Tennent-Brown, T. Goetz, M. Manohar, A. Hassan, D. Freeman, J. Bundy, M. Evans] Dehydration and the associated impairment of cardiovascular and thermoregulatory function comprise major veterinary problems in horses performing prolonged exercise, particularly under hot and humid conditions. For these reasons, there is considerable interest in using pre-exercise hyperhydration to help maintain blood volume in the face of the excessive fluid loss associated with sweat production during prolonged exertion. However, recently it was reported that pre-exercise hyperhydration causes arterial hypoxemia in horses performing moderate intensity exercise simulating the second day of an equestrian 3-day event competition (E3DEC) which may adversely affect performance (Sosa Leon et al. in Equine Vet J Suppl 34:425-429, 2002). These findings are contrary to data from horses performing short-term maximal exertion, wherein hyperhydration did not affect arterial O2 tension/saturation. Thus, our objective in the present study was to examine the impact of pre-exercise hyperhydration on arterial oxygenation of Thoroughbred horses performing an exercise test simulating the second day of an E3DEC. Control and hyperhydration studies were carried out on seven healthy Thoroughbred horses in random order, 7days apart. In the control study, horses received no medications. In the hyperhydration experiments, nasogastric administration of NaCl (0.425g/kg) 5h pre-exercise induced a plasma volume expansion of 10.9% at the initiation of exercise. This methodology for inducing hypervolemia was different from that of Sosa Leon et al. (2002). Blood-gas tensions/pH as well as plasma protein, hemoglobin and blood lactate concentrations were measured pre-exercise and during the exercise test. Our data revealed that pre-exercise hyperhydration neither adversely affected arterial O2 tension nor hemoglobin-O2 saturation at any time during the exercise test simulating the second day of an E3DEC. Further, it was observed that arterial blood CO2 tension, pH, and blood lactate concentrations also were not affected by pre-exercise hyperhydration. However, hemodilution in hyperhydrated horses caused an attenuation of the expansion in the arterial to mixed-venous blood O2 content gradient during phases B and D of the exercise protocol, which was likely offset by an increase in cardiac output. It is concluded that pre-exercise hyperhydration of horses induced in the manner described above is not detrimental to arterial oxygenation of horses performing an exercise test simulating the second day of an E3DEC. Springer-Verlag, 2006 Prolonged exercise nationallicence Blood-gas tensions during exertion nationallicence Hypervolemia nationallicence Exercise-induced arterial hypoxemia nationallicence Tennent-Brown B. Departments of Veterinary Clinical Medicine and Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 1008 West Hazelwood Drive, 61802, Urbana, IL, USA aut Goetz T. Departments of Veterinary Clinical Medicine and Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 1008 West Hazelwood Drive, 61802, Urbana, IL, USA aut Manohar M. Departments of Veterinary Clinical Medicine and Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 1008 West Hazelwood Drive, 61802, Urbana, IL, USA aut Hassan A. Departments of Veterinary Clinical Medicine and Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 1008 West Hazelwood Drive, 61802, Urbana, IL, USA aut Freeman D. Departments of Veterinary Clinical Medicine and Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 1008 West Hazelwood Drive, 61802, Urbana, IL, USA aut Bundy J. Departments of Veterinary Clinical Medicine and Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 1008 West Hazelwood Drive, 61802, Urbana, IL, USA aut Evans M. Departments of Veterinary Clinical Medicine and Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 1008 West Hazelwood Drive, 61802, Urbana, IL, USA aut European Journal of Applied Physiology Springer-Verlag 97/4(2006-07-01), 462-470 1439-6319 97:4<462 2006 97 421 https://doi.org/10.1007/s00421-006-0191-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0191-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tennent-Brown B. Departments of Veterinary Clinical Medicine and Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 1008 West Hazelwood Drive, 61802, Urbana, IL, USA aut NATIONALLICENCE 700 1- Goetz T. Departments of Veterinary Clinical Medicine and Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 1008 West Hazelwood Drive, 61802, Urbana, IL, USA aut NATIONALLICENCE 700 1- Manohar M. Departments of Veterinary Clinical Medicine and Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 1008 West Hazelwood Drive, 61802, Urbana, IL, USA aut NATIONALLICENCE 700 1- Hassan A. Departments of Veterinary Clinical Medicine and Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 1008 West Hazelwood Drive, 61802, Urbana, IL, USA aut NATIONALLICENCE 700 1- Freeman D. Departments of Veterinary Clinical Medicine and Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 1008 West Hazelwood Drive, 61802, Urbana, IL, USA aut NATIONALLICENCE 700 1- Bundy J. Departments of Veterinary Clinical Medicine and Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 1008 West Hazelwood Drive, 61802, Urbana, IL, USA aut NATIONALLICENCE 700 1- Evans M. Departments of Veterinary Clinical Medicine and Biosciences, College of Veterinary Medicine, University of Illinois at Urbana-Champaign, 1008 West Hazelwood Drive, 61802, Urbana, IL, USA aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 97/4(2006-07-01), 462-470 1439-6319 97:4<462 2006 97 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer