caa a22 4500 467942250 CHVBK 20180406153016.0 cr unu---uuuuu 170328e20060701xx s 000 0 eng 10.1007/s00421-006-0210-0 doi (NATIONALLICENCE)springer-10.1007/s00421-006-0210-0 Mechanisms behind the postprandial increase in cardiac output: a clue obtained from transplanted hearts [Elektronische Daten] [Bjarne Waaler, Jonny Hisdal, Halfdan Ihlen, John Kjekshus] Consumption of a meal is followed by an increase in cardiac output (CO) which appears to be closely related to the concomitant increase in blood flow to the gastrointestinal organs. To gain information on the mechanism behind this increase in CO we have previously used Doppler ultrasound technique to record circulatory responses to a standardized meal in five patients with recently transplanted and thus denervated hearts. We obtained the surprising result that they reacted to the consumption of a meal with a greater increase in CO than did five matched normal controls. The patients also presented above-normal levels of heart rate (HR) and CO at rest. The same five patients have now been tested 18months later to re-examine their remarkable cardiac response to ingestion of a meal. The hearts of two patients showed some signs of reinnervation, whereas the hearts of the other three were apparently still fully denervated. However, all five patients once again evolved a marked cardiac response to ingestion of a meal. Postprandial CO reached significantly higher levels in the patients than in the controls. The persistence of such a pronounced postprandial augmentation of CO in transplanted and largely denervated hearts strengthens the assumption that the heart is induced to increase its postprandial performance through the action of a humoral agent of some sort, possibly one of the hormones from the duodenal-pancreatic region Springer-Verlag, 2006 Cardiac output nationallicence Transplanted hearts nationallicence Postprandial circulation nationallicence Splanchnic circulation nationallicence Superior mesenteric artery nationallicence Secretin nationallicence Insulin nationallicence Waaler Bjarne Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Blindern, PO Box 1103, 0317, Oslo, Norway aut Hisdal Jonny Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Blindern, PO Box 1103, 0317, Oslo, Norway aut Ihlen Halfdan Heart Medical Section, Rikshospitalet University Hospital, Oslo, Norway aut Kjekshus John Heart Medical Section, Rikshospitalet University Hospital, Oslo, Norway aut European Journal of Applied Physiology Springer-Verlag 97/5(2006-07-01), 516-520 1439-6319 97:5<516 2006 97 421 https://doi.org/10.1007/s00421-006-0210-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0210-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Waaler Bjarne Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Blindern, PO Box 1103, 0317, Oslo, Norway aut NATIONALLICENCE 700 1- Hisdal Jonny Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Blindern, PO Box 1103, 0317, Oslo, Norway aut NATIONALLICENCE 700 1- Ihlen Halfdan Heart Medical Section, Rikshospitalet University Hospital, Oslo, Norway aut NATIONALLICENCE 700 1- Kjekshus John Heart Medical Section, Rikshospitalet University Hospital, Oslo, Norway aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 97/5(2006-07-01), 516-520 1439-6319 97:5<516 2006 97 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer