caa a22 4500 467942285 CHVBK 20180406153016.0 cr unu---uuuuu 170328e20060701xx s 000 0 eng 10.1007/s00421-006-0211-z doi (NATIONALLICENCE)springer-10.1007/s00421-006-0211-z Central adaptations during repetitive contractions assessed by the readiness potential [Elektronische Daten] [M. Schillings, J. Kalkman, S. van der Werf, G. Bleijenberg, B. van Engelen, M. Zwarts] Physiological fatigue, a loss of maximal force producing capacity, may originate both from changes at the peripheral and at the central level. The readiness potential (RP) provides a measure to study adaptations to physiological fatigue at the motor cortex. We have studied the RP in the course of repetitive contractions at a high force level. Fourteen female healthy subjects made repetitive force grip contractions at 70% of their maximal voluntary contraction (MVC) for 30min. Contractions were self-paced and inter-squeeze interval was about 7s. During the repetitive contractions, the area under the curve of the RP almost doubled at electrode Cz and increased fourfold at electrodes C3′ and C4′. The onset of negativity moved forward from 1.5 to 1.9s before force onset at Cz and from 1.0 to 1.6s and 1.7s before force onset at C3′ and C4′, respectively. EMG amplitude and median frequency did not change significantly and MVC after the fatiguing exercise was 93% of MVC before, indicating relatively little physiological fatigue. The increase of the RP during the repetitive contractions is clearly in excess of the almost absent signs of peripheral fatigue. Because the increase of the RP does not lead to an increased force production, we propose that it is a central adaptation counteracting the decrease of cortical efficiency during repetitive contractions. Springer-Verlag, 2006 Motor-activity related cortical potential nationallicence Bereitschaftspotential nationallicence Electroencephalography nationallicence Repetitive voluntary contraction nationallicence Movement-related cortical potential nationallicence Schillings M. Department of Clinical Neurophysiology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands aut Kalkman J. Expert Centre Chronic Fatigue, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut van der Werf S. Department of Medical Psychology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut Bleijenberg G. Expert Centre Chronic Fatigue, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut van Engelen B. Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut Zwarts M. Department of Clinical Neurophysiology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands aut European Journal of Applied Physiology Springer-Verlag 97/5(2006-07-01), 521-526 1439-6319 97:5<521 2006 97 421 https://doi.org/10.1007/s00421-006-0211-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0211-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schillings M. Department of Clinical Neurophysiology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Kalkman J. Expert Centre Chronic Fatigue, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- van der Werf S. Department of Medical Psychology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Bleijenberg G. Expert Centre Chronic Fatigue, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- van Engelen B. Department of Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands aut NATIONALLICENCE 700 1- Zwarts M. Department of Clinical Neurophysiology, Radboud University Nijmegen Medical Centre, P.O. Box 9101, 6500 HB, Nijmegen, The Netherlands aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 97/5(2006-07-01), 521-526 1439-6319 97:5<521 2006 97 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer