caa a22 4500 467942374 CHVBK 20180406153016.0 cr unu---uuuuu 170328e20060501xx s 000 0 eng 10.1007/s00421-006-0163-3 doi (NATIONALLICENCE)springer-10.1007/s00421-006-0163-3 Increase of adiponectin receptor gene expression by physical exercise in soleus muscle of obese Zucker rats [Elektronische Daten] [Shih-Pei Chang, Yu-Hsuan Chen, Weng-Cheng Chang, I-Min Liu, Juei-Tang Cheng] Aerobic exercise, including treadmill running has been widely used to treat insulin resistance and type 2 diabetes. We studied the effects of endurance training on gene expression of adiponectin receptor 1 (AdipoR1) in skeletal muscle of obese Zucker rats: the 8-week moderate exercise program consisted of treadmill running at 20m/min and 0° gradient for 1h/day, 7days/week. After 8weeks, insulin action on glucose disposal rate was measured by glucose-insulin index, the product of the areas under the curve of glucose and insulin during intraperitoneal glucose tolerance testing. In contrast to results for sedentary obese rats, exercise training decreased plasma levels of insulin and glucose as well as the glucose-insulin index in obese rats, indicating the merit of regular moderate exercise for improvement of insulin sensitivity in this insulin-resistant animal model. Also, diabetes-related reductions in mRNA and protein content of AdipoR1 in soleus muscle were observed in obese rats at baseline; they were markedly reversed after the 8-week exercise program. However, such exercise training did not alter plasma levels of insulin and glucose in lean Zucker rats. Also, AdipoR1 gene expression in soleus muscle was not changed by exercise in lean Zucker rats compared with the sedentary, lean littermates. These results suggest that long-term exercise training may reverse reduced AdipoR1 gene expression in soleus muscle and improve insulin sensitivity in the obese Zucker rats. Thus, an endurance exercise training is probably helpful clinically for obese individuals with insulin resistance. Springer-Verlag, 2006 Adiponectin receptor 1 nationallicence Exercise nationallicence Insulin resistance nationallicence Soleus muscle nationallicence Zucker rats nationallicence Chang Shih-Pei Department of Physical Education and Department of Medical Technology, Central Taiwan University of Science and Technology, 4060, Taichung City, Taiwan, R.O.C. aut Chen Yu-Hsuan Department of Physical Education and Department of Medical Technology, Central Taiwan University of Science and Technology, 4060, Taichung City, Taiwan, R.O.C. aut Chang Weng-Cheng Department of Sports Medicine, China Medical University, 40401, Taichung City, Taiwan, R.O.C. aut Liu I-Min Department of Pharmacy, Tajen University, Yen-Pou, 90701, Ping Tung Shien, Taiwan, R.O.C. aut Cheng Juei-Tang Department of Pharmacology, College of Medicine, National Cheng Kung University, 70101, Tainan City, Taiwan, R.O.C. aut European Journal of Applied Physiology Springer-Verlag 97/2(2006-05-01), 189-195 1439-6319 97:2<189 2006 97 421 https://doi.org/10.1007/s00421-006-0163-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0163-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chang Shih-Pei Department of Physical Education and Department of Medical Technology, Central Taiwan University of Science and Technology, 4060, Taichung City, Taiwan, R.O.C aut NATIONALLICENCE 700 1- Chen Yu-Hsuan Department of Physical Education and Department of Medical Technology, Central Taiwan University of Science and Technology, 4060, Taichung City, Taiwan, R.O.C aut NATIONALLICENCE 700 1- Chang Weng-Cheng Department of Sports Medicine, China Medical University, 40401, Taichung City, Taiwan, R.O.C aut NATIONALLICENCE 700 1- Liu I-Min Department of Pharmacy, Tajen University, Yen-Pou, 90701, Ping Tung Shien, Taiwan, R.O.C aut NATIONALLICENCE 700 1- Cheng Juei-Tang Department of Pharmacology, College of Medicine, National Cheng Kung University, 70101, Tainan City, Taiwan, R.O.C aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 97/2(2006-05-01), 189-195 1439-6319 97:2<189 2006 97 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer