caa a22 4500 467942420 CHVBK 20180406153017.0 cr unu---uuuuu 170328e20060501xx s 000 0 eng 10.1007/s00421-006-0161-5 doi (NATIONALLICENCE)springer-10.1007/s00421-006-0161-5 Effects of exercise training on pathological cardiac hypertrophy related gene expression and apoptosis [Elektronische Daten] [Young Lee, Joon Cho, Mun Kim, Kee Kim, Dong Lee, Kyu Lee] This study determined whether exercise training prevents pathological hypertrophy in the left ventricle by modulation of myocardial and apoptosis-associated genes. We used spontaneously hypertensive rats (n=15, non-exercise SHR), exercise-trained SHR (n=15, treadmill exercise for 12weeks), and sedentary Wistar-Kyoto (WKY) rats (n=15). Exercise-trained SHR expressed adaptive changes such as reduced body weight, heart rate, blood pressures, left ventricle wall thickness, lipid profiles, and homocysteine level. The mRNA expression of angiotensin converting enzyme, endothelin-1, and brain natriuretic peptides in the heart was lower in the exercise-trained SHR and in the WKY than in the non-exercise SHR, whereas mRNA expression of caveolin-3 and eNOS in the heart was higher. Bcl-2 protein was higher in the exercise-trained SHR than in the WKY and the non-exercise SHR. In contrast, Bax protein levels were lower in the exercise-trained SHR and in the WKY than in the non-exercise SHR. Furthermore, the levels of the active forms of caspase-3 (20kDa) were lower in the exercise-trained SHR and in the WKY than in the non-exercise SHR. These findings suggest that exercise training prevents pathological hypertrophy in the left ventricle by modulation of myocardial genes and that it interferes with a signal transduction pathway of apoptosis secondary to the pathological cardiac hypertrophy. Springer-Verlag, 2006 Pathological cardiac hypertrophy nationallicence Apoptosis nationallicence Gene expression nationallicence Exercise training nationallicence Lee Young Exercise Biochemistry Laboratory, Korea National Sport University, 88-15 Oryun-dong, 138-763, Songpa-gu, Seoul, Korea aut Cho Joon Exercise Biochemistry Laboratory, Korea National Sport University, 88-15 Oryun-dong, 138-763, Songpa-gu, Seoul, Korea aut Kim Mun Exercise Biochemistry Laboratory, Korea National Sport University, 88-15 Oryun-dong, 138-763, Songpa-gu, Seoul, Korea aut Kim Kee Department of Physical Education, SungKyul University, 147-2 Anyang-8-dong, Manan-gu, 430-742, Anyang-city, Kyonggi-do, Korea aut Lee Dong Institute of Sports and Science, KyungHee University, 1 Sochen-ni, Kihung-eop, 449-701, Yongin-shi, Kyongki-do, Korea aut Lee Kyu Exercise Biochemistry Laboratory, Korea National Sport University, 88-15 Oryun-dong, 138-763, Songpa-gu, Seoul, Korea aut European Journal of Applied Physiology Springer-Verlag 97/2(2006-05-01), 216-224 1439-6319 97:2<216 2006 97 421 https://doi.org/10.1007/s00421-006-0161-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00421-006-0161-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lee Young Exercise Biochemistry Laboratory, Korea National Sport University, 88-15 Oryun-dong, 138-763, Songpa-gu, Seoul, Korea aut NATIONALLICENCE 700 1- Cho Joon Exercise Biochemistry Laboratory, Korea National Sport University, 88-15 Oryun-dong, 138-763, Songpa-gu, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Mun Exercise Biochemistry Laboratory, Korea National Sport University, 88-15 Oryun-dong, 138-763, Songpa-gu, Seoul, Korea aut NATIONALLICENCE 700 1- Kim Kee Department of Physical Education, SungKyul University, 147-2 Anyang-8-dong, Manan-gu, 430-742, Anyang-city, Kyonggi-do, Korea aut NATIONALLICENCE 700 1- Lee Dong Institute of Sports and Science, KyungHee University, 1 Sochen-ni, Kihung-eop, 449-701, Yongin-shi, Kyongki-do, Korea aut NATIONALLICENCE 700 1- Lee Kyu Exercise Biochemistry Laboratory, Korea National Sport University, 88-15 Oryun-dong, 138-763, Songpa-gu, Seoul, Korea aut NATIONALLICENCE 773 0- European Journal of Applied Physiology Springer-Verlag 97/2(2006-05-01), 216-224 1439-6319 97:2<216 2006 97 421 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer