caa a22 4500 467943877 CHVBK 20180405193735.0 cr unu---uuuuu 170328e20050201xx s 000 0 eng 10.1007/s11055-005-0006-4 doi (NATIONALLICENCE)springer-10.1007/s11055-005-0006-4 (NATIONALLICENCE)springer-10.1007/s11055-005-0056-7 Aftereffects of microinjections of Neurotensin into the Substantia Nigra of the brain on conditioned motor responses in Rats with lesions to Serotoninergic neurons [Elektronische Daten] [N. Shugalev, G. Khartmann, E. Kertesh] The effects of neurotensin microinjections into the substantia nigra of the brain on the performance of motor reactions in response to positive (food reinforcement) and negative (unreinforced) conditioned signals were studied, along with the characteristic aftereffects of these microinjections in rats with lesions to serotoninergic neurons in the dorsal cervical nucleus. Lesions were produced by local administration of the selective neurotoxin 5,7-dihydroxytryptamine. Microinjections of neurotensin were found to weaken the disinhibitory effects of neurotoxin on extinction of intersignal responses and extinction of conditioned motor reactions in response to presentation of negative stimuli, but to have no marked effect on the performance of reactions evoked by positive conditioned signals. Changes persisted into subsequent experiments without peptide microinjections. Measurements of the level of preference of the animals for one quadrant of the experimental chamber showed that operated rats avoided occupying the test quadrant and preferred to locate themselves in the opposite quadrant. Neurotensin released this effect of the neurotoxin. These results lead to the conclusion that these behavioral effects of neurotensin are associated with its normalizing influences on the motivational-emotional state of the animals with lesions to serotoninergic neurons and may also be due to the formation in the animals of a contextual conditioned emotional state, which aids optimization of the adaptive functions of the brain. Springer Science+Business Media, Inc., 2005 neurotensin nationallicence neurotoxin nationallicence dopamine nationallicence serotonin nationallicence substantia nigra nationallicence conditioned reflex nationallicence motor activity nationallicence aftereffects nationallicence conditioned reflex preference nationallicence Shugalev N. Science Research Institute of the Brain, Russian Academy of Medical Sciences, Moscow aut Khartmann G. Science Research Institute of the Brain, Russian Academy of Medical Sciences, Moscow aut Kertesh E. Science Research Institute of the Brain, Russian Academy of Medical Sciences, Moscow aut Neuroscience and Behavioral Physiology Kluwer Academic Publishers-Consultants Bureau 35/2(2005-02-01), 147-151 0097-0549 35:2<147 2005 35 11055 https://doi.org/10.1007/s11055-005-0006-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11055-005-0006-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shugalev N. Science Research Institute of the Brain, Russian Academy of Medical Sciences, Moscow aut NATIONALLICENCE 700 1- Khartmann G. Science Research Institute of the Brain, Russian Academy of Medical Sciences, Moscow aut NATIONALLICENCE 700 1- Kertesh E. Science Research Institute of the Brain, Russian Academy of Medical Sciences, Moscow aut NATIONALLICENCE 773 0- Neuroscience and Behavioral Physiology Kluwer Academic Publishers-Consultants Bureau 35/2(2005-02-01), 147-151 0097-0549 35:2<147 2005 35 11055 NATIONALLICENCE 856 40 https://doi.org/10.1007/s11055-005-0056-7 text/html Onlinezugriff via DOI Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE NATIONALLICENCE NL-springer