caa a22 4500 467943885 CHVBK 20180405193735.0 cr unu---uuuuu 170328e20050301xx s 000 0 eng 10.1007/s11055-005-0051-z doi (NATIONALLICENCE)springer-10.1007/s11055-005-0051-z (NATIONALLICENCE)springer-10.1007/PL00022038 Sem'yanov A. Institute of Neurology, London, UK aut Diffusional extrasynaptic neurotransmission via glutamate and GABA [Elektronische Daten] [A. Sem'yanov] Glutamate and GABA are the main synaptic neurotransmitters in the hippocampus. However, their actions are not limited only to the local postsynaptic zone. These amino acids can be released into the extrasynaptic space by glutamate and GABA reuptake, glial exocytosis, osmotic shock, and spillover (flowing out of the synaptic cleft). Glutamate and GABA receptors are also located on various parts of neurons and glial cells. Depending on the subcellular distribution of these receptors, their subunit composition, and the matabotropic/ionotropic functions, the effects of extracellular glutamate and GABA differ. The present review discusses the general principles of the organization of diffusion-based glutamatergic and GABAergic systems of extrasynaptic neurotransmission, the interaction of these systems with synaptic transmission, and the interaction of diffusion signals with each other. Springer Science+Business Media, Inc., 2005 glia nationallicence spillover nationallicence transporters nationallicence extrasynaptic receptors nationallicence diffusion nationallicence glia nationallicence Neuroscience and Behavioral Physiology Kluwer Academic Publishers-Consultants Bureau 35/3(2005-03-01), 253-266 0097-0549 35:3<253 2005 35 11055 https://doi.org/10.1007/s11055-005-0051-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11055-005-0051-z text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Sem'yanov A. Institute of Neurology, London, UK aut NATIONALLICENCE 773 0- Neuroscience and Behavioral Physiology Kluwer Academic Publishers-Consultants Bureau 35/3(2005-03-01), 253-266 0097-0549 35:3<253 2005 35 11055 NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00022038 text/html Onlinezugriff via DOI Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE NATIONALLICENCE NL-springer