caa a22 4500 467943966 CHVBK 20180405193735.0 cr unu---uuuuu 170328e20050201xx s 000 0 eng 10.1007/s11055-005-0054-9 doi (NATIONALLICENCE)springer-10.1007/s11055-005-0054-9 (NATIONALLICENCE)springer-10.1007/s11055-005-0005-5 Age-related changes in the characteristics of evoked responses in field CA1 in rat hippocampus slices after deafferentation of the forelimb [Elektronische Daten] [I. Kudryashov, I. Kudryashova] The effects of in situ transection of the median nerve in baby rats on the formation of the properties of synaptic transmission in the hippocampus were studied. Paired-pulse stimulation was used to identify the characteristics of short-term facilitation in living slices. Significant deviations in the time dynamics of facilitation from control values were seen in operated animals. Analysis showed that the decrease in the population spike amplitude, which we have described previously, may be due not only to functional causes, but also to morphological causes - elimination of neurons and their processes. It is suggested that a period of destructive changes is followed by the onset of a phase of intense formation of new synaptic contacts. The nature of the heterochrony of electrophysiological measures does not lead to any conclusion as to whether the maturation of intrahippocampal systems leads or lags in the experimental baby rats. It is suggested that hippocampal development along a new, abnormal pathway is induced. Springer Science+Business Media, Inc., 2005 ontogenesis nationallicence hippocampal slices nationallicence field CA1 nationallicence population spikes nationallicence synaptic efficiency nationallicence paired-pulse facilitation nationallicence Kudryashov I. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow aut Kudryashova I. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow aut Neuroscience and Behavioral Physiology Kluwer Academic Publishers-Consultants Bureau 35/2(2005-02-01), 139-146 0097-0549 35:2<139 2005 35 11055 https://doi.org/10.1007/s11055-005-0054-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11055-005-0054-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kudryashov I. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow aut NATIONALLICENCE 700 1- Kudryashova I. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow aut NATIONALLICENCE 773 0- Neuroscience and Behavioral Physiology Kluwer Academic Publishers-Consultants Bureau 35/2(2005-02-01), 139-146 0097-0549 35:2<139 2005 35 11055 NATIONALLICENCE 856 40 https://doi.org/10.1007/s11055-005-0005-5 text/html Onlinezugriff via DOI Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE NATIONALLICENCE NL-springer