caa a22 4500 467943990 CHVBK 20180323165659.0 cr unu---uuuuu 170328e19881201xx s 000 0 eng 10.1007/BF00553874 doi (NATIONALLICENCE)springer-10.1007/BF00553874 (NATIONALLICENCE)springer-10.1007/BF02395521 DNA rearrangement causes multiple changes in gene expression at the amylase locus in Drosophila melanogaster [Elektronische Daten] [Donal Hickey, Bernhard Benkel, Sumaia Abukashawa, Susanne Haus] A spontaneous null mutation at the α-amylase locus inDrosophila melanogaster was recovered from a laboratory population. The mutant strain was found to lack amylase enzyme production and to produce low, but detectable, levels of amylase mRNA. Moreover, the null strain is also lacking the glucose repression of amylase mRNA production which is seen in wild-type strains. The mutant phenotype correlates with a rearrangement in genomic DNA which, in turn, corresponds to a simple inversion in the arrangement observed most frequently in North American populations ofD. melanogaster, including the common laboratory strain, Oregon-R. These results have implications for our understanding of both the evolution of the duplicated amylase gene structure and the regulation of amylase gene expression. Plenum Publishing Corporation, 1988 DNA rearrangement nationallicence amylase locus nationallicence Drosophila melanogaster nationallicence Hickey Donal Department of Biology, University of Ottawa, K1N 6N5, Ottawa, Ontario, Canada aut Benkel Bernhard Department of Biology, University of Ottawa, K1N 6N5, Ottawa, Ontario, Canada aut Abukashawa Sumaia Department of Biology, University of Ottawa, K1N 6N5, Ottawa, Ontario, Canada aut Haus Susanne Department of Biological Sciences, Brock University, L1S 2A1, St. Catharines, Ontario, Canada aut Biochemical Genetics Kluwer Academic Publishers-Plenum Publishers 26/11-12(1988-12-01), 757-768 0006-2928 26:11-12<757 1988 26 10528 https://doi.org/10.1007/BF00553874 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00553874 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hickey Donal Department of Biology, University of Ottawa, K1N 6N5, Ottawa, Ontario, Canada aut NATIONALLICENCE 700 1- Benkel Bernhard Department of Biology, University of Ottawa, K1N 6N5, Ottawa, Ontario, Canada aut NATIONALLICENCE 700 1- Abukashawa Sumaia Department of Biology, University of Ottawa, K1N 6N5, Ottawa, Ontario, Canada aut NATIONALLICENCE 700 1- Haus Susanne Department of Biological Sciences, Brock University, L1S 2A1, St. Catharines, Ontario, Canada aut NATIONALLICENCE 773 0- Biochemical Genetics Kluwer Academic Publishers-Plenum Publishers 26/11-12(1988-12-01), 757-768 0006-2928 26:11-12<757 1988 26 10528 NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02395521 text/html Onlinezugriff via DOI Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE NATIONALLICENCE NL-springer