caa a22 4500 467945772 CHVBK 20180405193737.0 cr unu---uuuuu 170328e20050201xx s 000 0 eng 10.1007/s11055-005-0068-3 doi (NATIONALLICENCE)springer-10.1007/s11055-005-0068-3 (NATIONALLICENCE)springer-10.1007/s11055-005-0012-6 Function of the hypothalamo-hypophyseal-adrenal system in mice with ectopic hyperproduction of the agouti protein [Elektronische Daten] [N. Karkaeva, N. Bazhan, T. Yakovleva, E. Makarova] The agouti protein is known to compete with the melanocortin hormones (ACTH, melanocyte-stimulating hormone) at melanocortin receptors, which in turn are involved in controlling the central and peripheral components of the hypothalamo-hypophyseal-adrenal system. The aim of the present work was therefore to assess the effects of the dominant mutation Agouti yellow (A y/a), which induces ectopic hyperproduction of the agouti protein and yellow coat color, on the function of the hypothalamo-hypophyseal-adrenal system. Experiments were performed on male A y/a mice of the C57BI/6J line. Controls consisted of mice of the same line bearing the recessive mutation nonagouti (a/a), which leads to the absence of agouti protein and black coat color. The experimental results showed that mice with different agouti genotypes had identical basal corticosterone levels, though yellow mice, as compared with black mice, had increased corticosterone levels after restriction stress (p < 0.02), along with decreased stress reactivity after treatment with dexamethasone (p < 0.0007), and increased adrenal sensitivity to small doses of activity, both in vitro and in vivo. Springer Science+Business Media, Inc., 2005 agouti protein nationallicence mutations in the agouti gene nationallicence the hypothalamo-hypophyseal-adrenal system nationallicence stress reactivity nationallicence dexamethasone nationallicence Karkaeva N. Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, 10 Lavrent'ev Prospekt, 630090, Novosibirsk, Russia aut Bazhan N. Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, 10 Lavrent'ev Prospekt, 630090, Novosibirsk, Russia aut Yakovleva T. Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, 10 Lavrent'ev Prospekt, 630090, Novosibirsk, Russia aut Makarova E. Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, 10 Lavrent'ev Prospekt, 630090, Novosibirsk, Russia aut Neuroscience and Behavioral Physiology Kluwer Academic Publishers-Consultants Bureau 35/2(2005-02-01), 187-191 0097-0549 35:2<187 2005 35 11055 https://doi.org/10.1007/s11055-005-0068-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11055-005-0068-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Karkaeva N. Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, 10 Lavrent'ev Prospekt, 630090, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Bazhan N. Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, 10 Lavrent'ev Prospekt, 630090, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Yakovleva T. Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, 10 Lavrent'ev Prospekt, 630090, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Makarova E. Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, 10 Lavrent'ev Prospekt, 630090, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Neuroscience and Behavioral Physiology Kluwer Academic Publishers-Consultants Bureau 35/2(2005-02-01), 187-191 0097-0549 35:2<187 2005 35 11055 NATIONALLICENCE 856 40 https://doi.org/10.1007/s11055-005-0012-6 text/html Onlinezugriff via DOI Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE NATIONALLICENCE NL-springer