caa a22 4500 467945888 CHVBK 20180323165700.0 cr unu---uuuuu 170328e19891001xx s 000 0 eng 10.1007/BF02396156 doi (NATIONALLICENCE)springer-10.1007/BF02396156 (NATIONALLICENCE)springer-10.1007/BF00553636 Genetic and tissue-specific variation in the expression of a closely linked murine multigene family on chromosome 15 that encodes salivary and lacrimal proteins [Elektronische Daten] [D. Dickinson, K. Abel, J. Near, B. Taylor, K. Gross] The murine submandibular gland (SMG) produces a novel class of highly acidic salivary proteins encoded by one or more highly abundant mRNA transcripts. In inbred mice, these transcripts are encoded by members of a multigene family comprising approximately 8-12 homologues. Most, and probably all, of these homologues are clustered at a new locus near belted (bt) on chromosome 15, which we designateSpt (salivary protein). Although physically closely linked,Spt genes differ in their patterns of expression both in strains of mice and in their tissues. One gene,Spt-1, is expressed at high levels in the SMG of all inbred strains examined. This gene is also expressed at significant levels in the lacrimal gland. A second gene,Spt-2, appears to be present as a single copy in some strains and as two copies in others. This gene is expressed at high levels only in the SMG of those strains carrying two copies, andSpt-2 mRNA is not detectable in the SMG of strains carrying only one copy. In contrast toSpt-1, theSpt-2 gene is not expressed at detectable levels in the lacrimal gland. Plenum Publishing Corporation, 1989 mouse nationallicence salivary protein nationallicence lacrimal protein nationallicence gene expression nationallicence Spt locus nationallicence multigene family nationallicence Dickinson D. Department of Molecular and Cellular Biology, Roswell Park Memorial Institute, 14263, Buffalo, New York aut Abel K. Department of Molecular and Cellular Biology, Roswell Park Memorial Institute, 14263, Buffalo, New York aut Near J. Department of Biology, State University College at Buffalo, 14222, Buffalo, New York aut Taylor B. The Jackson Laboratory, 04609, Bar Harbor, Maine aut Gross K. Department of Molecular and Cellular Biology, Roswell Park Memorial Institute, 14263, Buffalo, New York aut Biochemical Genetics Kluwer Academic Publishers-Plenum Publishers 27/9-10(1989-10-01), 613-637 0006-2928 27:9-10<613 1989 27 10528 https://doi.org/10.1007/BF02396156 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02396156 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Dickinson D. Department of Molecular and Cellular Biology, Roswell Park Memorial Institute, 14263, Buffalo, New York aut NATIONALLICENCE 700 1- Abel K. Department of Molecular and Cellular Biology, Roswell Park Memorial Institute, 14263, Buffalo, New York aut NATIONALLICENCE 700 1- Near J. Department of Biology, State University College at Buffalo, 14222, Buffalo, New York aut NATIONALLICENCE 700 1- Taylor B. The Jackson Laboratory, 04609, Bar Harbor, Maine aut NATIONALLICENCE 700 1- Gross K. Department of Molecular and Cellular Biology, Roswell Park Memorial Institute, 14263, Buffalo, New York aut NATIONALLICENCE 773 0- Biochemical Genetics Kluwer Academic Publishers-Plenum Publishers 27/9-10(1989-10-01), 613-637 0006-2928 27:9-10<613 1989 27 10528 NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00553636 text/html Onlinezugriff via DOI Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE NATIONALLICENCE NL-springer