caa a22 4500 467945918 CHVBK 20180323165700.0 cr unu---uuuuu 170328e19881201xx s 000 0 eng 10.1007/BF00553876 doi (NATIONALLICENCE)springer-10.1007/BF00553876 (NATIONALLICENCE)springer-10.1007/BF02395523 Genetic characterization of dipeptidase activity modifiers in Drosophila melanogaster from natural populations [Elektronische Daten] [Kazuo Hiraizumi, Cathy Laurie] An examination ofDrosophila melanogaster from natural populations revealed genetic variation for dipeptidase-A (DIP-A) and dipeptidase-B (DIP-B) activities within sets of lines that differed from one another only in the second or the third chromosome. Analyses of diallel crosses indicate that both activities are inherited additively, and coordinate control of expression is suggested by the significant positive correlation between the two activities. Electrophoresis and thermal denaturation studies failed to detect structural differences among lines with different levels of DIP-A activity. No characteristic level of activity could be associated with any DIP-A allozyme. Mapping experiments revealed the presence of activity modifiers that are in tight linkage with the structural gene, as well as those that manifest their effects from a distance. The maximum genetic distance between a high-activity effect on DIP-A and the structural gene was determined to be 0.029 map unit. These results are in accordance with the prevalence of activity modifiers for various enzymes inDrosophila melanogaster. Plenum Publishing Corporation, 1988 Drosophila nationallicence dipeptidase activities nationallicence genetic variation nationallicence activity modifiers nationallicence Hiraizumi Kazuo Department of Genetics, North Carolina State University, 27695, Raleigh, North Carolina aut Laurie Cathy Department of Genetics, North Carolina State University, 27695, Raleigh, North Carolina aut Biochemical Genetics Kluwer Academic Publishers-Plenum Publishers 26/11-12(1988-12-01), 783-803 0006-2928 26:11-12<783 1988 26 10528 https://doi.org/10.1007/BF00553876 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00553876 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hiraizumi Kazuo Department of Genetics, North Carolina State University, 27695, Raleigh, North Carolina aut NATIONALLICENCE 700 1- Laurie Cathy Department of Genetics, North Carolina State University, 27695, Raleigh, North Carolina aut NATIONALLICENCE 773 0- Biochemical Genetics Kluwer Academic Publishers-Plenum Publishers 26/11-12(1988-12-01), 783-803 0006-2928 26:11-12<783 1988 26 10528 NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02395523 text/html Onlinezugriff via DOI Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE NATIONALLICENCE NL-springer