caa a22 4500 467946558 CHVBK 20180405193737.0 cr unu---uuuuu 170328e20050101xx s 000 0 eng 10.1007/s10541-005-0047-x doi (NATIONALLICENCE)springer-10.1007/s10541-005-0047-x (NATIONALLICENCE)springer-10.1007/PL00021748 Analysis of interactions of DNA polymerase β and reverse transcriptases of human immunodeficiency and mouse leukemia viruses with dNTP analogs containing a modified sugar residue [Elektronische Daten] [N. Lebedeva, T. Seredina, V. Silnikov, T. Abramova, A. Levina, S. Khodyreva, N. Rechkunova, O. Lavrik] Substrate properties of various morpholinonucleoside triphosphates in the reaction of DNA elongation catalyzed by DNA polymerase β, reverse transcriptase of human immunodeficiency virus (HIV-1 RT), and reverse transcriptase of Moloney murine leukemia virus (M-MuLV RT) were compared. Morpholinonucleoside triphosphates were utilized by DNA polymerase β and HIV-1 reverse transcriptase as substrates, which terminated further synthesis of DNA, but were virtually not utilized by M-MuLV reverse transcriptase. The kinetic parameters of morpholinoderivatives of cytosine (MorC) and uridine (MorU) were determined in the reaction of primer elongation catalyzed by DNA polymerase β and HIV-1 reverse transcriptase. MorC was a more effective substrate of HIV-1 reverse transcriptase and significantly less effective substrate of DNA polymerase β than MorU. The possible use of morpholinonucleoside triphosphates as selective inhibitors of HIV-1 reverse transcriptase is discussed. MAIK "Nauka/Interperiodica”, 2005 viral reverse transcriptases nationallicence terminating substrates nationallicence DNA polymerase β nationallicence selective inhibition of viral DNA polymerases nationallicence Lebedeva N. Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, pr. Lavrentieva 8, 630090, Novosibirsk, Russia aut Seredina T. Novosibirsk State University, ul. Pirogova 2, 630090, Novosibirsk, Russia aut Silnikov V. Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, pr. Lavrentieva 8, 630090, Novosibirsk, Russia aut Abramova T. Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, pr. Lavrentieva 8, 630090, Novosibirsk, Russia aut Levina A. Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, pr. Lavrentieva 8, 630090, Novosibirsk, Russia aut Khodyreva S. Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, pr. Lavrentieva 8, 630090, Novosibirsk, Russia aut Rechkunova N. Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, pr. Lavrentieva 8, 630090, Novosibirsk, Russia aut Lavrik O. Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, pr. Lavrentieva 8, 630090, Novosibirsk, Russia aut Biochemistry (Moscow) Nauka/Interperiodica 70/1(2005-01-01), 1-7 0006-2979 70:1<1 2005 70 10541 https://doi.org/10.1007/s10541-005-0047-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10541-005-0047-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lebedeva N. Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, pr. Lavrentieva 8, 630090, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Silnikov V. Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, pr. Lavrentieva 8, 630090, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Abramova T. Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, pr. Lavrentieva 8, 630090, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Levina A. Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, pr. Lavrentieva 8, 630090, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Khodyreva S. Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, pr. Lavrentieva 8, 630090, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Rechkunova N. Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, pr. Lavrentieva 8, 630090, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Lavrik O. Institute of Chemical Biology and Fundamental Medicine, Siberian Division of the Russian Academy of Sciences, pr. Lavrentieva 8, 630090, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Seredina T. Novosibirsk State University, ul. Pirogova 2, 630090, Novosibirsk, Russia aut NATIONALLICENCE 773 0- Biochemistry (Moscow) Nauka/Interperiodica 70/1(2005-01-01), 1-7 0006-2979 70:1<1 2005 70 10541 NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00021748 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Silnikov V. Siberian Division of the Russian Academy of Sciences, Institute of Chemical Biology and Fundamental Medicine, pr. Lavrentieva 8, 630090, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Abramova T. Siberian Division of the Russian Academy of Sciences, Institute of Chemical Biology and Fundamental Medicine, pr. Lavrentieva 8, 630090, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Levina A. Siberian Division of the Russian Academy of Sciences, Institute of Chemical Biology and Fundamental Medicine, pr. Lavrentieva 8, 630090, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Khodyreva S. Siberian Division of the Russian Academy of Sciences, Institute of Chemical Biology and Fundamental Medicine, pr. Lavrentieva 8, 630090, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Rechkunova N. Siberian Division of the Russian Academy of Sciences, Institute of Chemical Biology and Fundamental Medicine, pr. Lavrentieva 8, 630090, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Lavrik O. Siberian Division of the Russian Academy of Sciences, Institute of Chemical Biology and Fundamental Medicine, pr. Lavrentieva 8, 630090, Novosibirsk, Russia aut NATIONALLICENCE 700 1- Lebedeva N. Siberian Division of the Russian Academy of Sciences, Institute of Chemical Biology and Fundamental Medicine, pr. Lavrentieva 8, 630090, Novosibirsk, Russia aut Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE NATIONALLICENCE NL-springer