caa a22 4500 467948593 CHVBK 20180915131427.0 cr unu---uuuuu 170328e19891201xx s 000 0 eng 10.1007/BF02396060 doi (NATIONALLICENCE)springer-10.1007/BF02396060 (NATIONALLICENCE)springer-10.1007/BF00553989 Molecular structure of a naturally occurring alcohol dehydrogenase null activity allele in Drosophila melanogaster [Elektronische Daten] [John Gibson, Ann Wilks] An alcohol dehydrogenase null activity allele,Adh nAH52 , extracted from a natural population ofDrosophila melanogaster has been cloned and sequenced. Compared with the wild-type consensus sequence, the nucleotide sequence ofAdh nAH52 contains eight extra bases in intron 2, adjacent to the 5' splice site. It seems likely that the extra bases result from two structural changes, with a 10-base pair insertion at the same site as a 2-base pair deletion. The insertion includes an 8-base pair duplication of an adjoining region. This structural change alters transcription to give rise to an mRNA which is longer than normal and at 10% of the wild-type level. Plenum Publishing Corporation, 1989 alcohol dehydrogenase nationallicence null allele nationallicence DNA rearrangement nationallicence Drosophila melanogaster nationallicence Gibson John Molecular and Population Genetics Group, Research School of Biological Sciences, The Australian National University, 2601, Canberra, A.C.T. aut Wilks Ann Molecular and Population Genetics Group, Research School of Biological Sciences, The Australian National University, 2601, Canberra, A.C.T. aut Biochemical Genetics Kluwer Academic Publishers-Plenum Publishers 27/11-12(1989-12-01), 679-688 0006-2928 27:11-12<679 1989 27 10528 https://doi.org/10.1007/BF02396060 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02396060 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Gibson John Molecular and Population Genetics Group, Research School of Biological Sciences, The Australian National University, 2601, Canberra, A.C.T aut NATIONALLICENCE 700 1- Wilks Ann Molecular and Population Genetics Group, Research School of Biological Sciences, The Australian National University, 2601, Canberra, A.C.T aut NATIONALLICENCE 773 0- Biochemical Genetics Kluwer Academic Publishers-Plenum Publishers 27/11-12(1989-12-01), 679-688 0006-2928 27:11-12<679 1989 27 10528 NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00553989 text/html Onlinezugriff via DOI Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 467948593 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE NATIONALLICENCE NL-springer