caa a22 4500 467949794 CHVBK 20180323165702.0 cr unu---uuuuu 170328e19880901xx s 000 0 eng 10.1007/BF01982910 doi (NATIONALLICENCE)springer-10.1007/BF01982910 (NATIONALLICENCE)springer-10.1007/BF00939315 Phosphate repressible and inhibitable β-lactam synthetases in Cephalosporium acremonium strain C-10 [Elektronische Daten] [Jinyou Zhang, Saul Wolfe, Arnold Demain] Summary: β-Lactam production by a high producer,Cephalosporium acremonium C-10, was reduced by high concentrations of phosphate (100 mM to 215 mM). The optimal concentration for antibiotic production by this strain was 25 mM. High concentrations of phosphate did not act by increasing the rate of glucose assimilation as previously concluded (Küenzi 1980). The three β-lactam synthetases tested, i.e., δ-(l-α-aminoadipyl)-l-cysteinyl-d-valine synthetase, cyclase and expandase, were all subject to phosphate repression as well as inhibition. The most susceptible to both kinds of regulation was the expandase. Springer-Verlag, 1988 Zhang Jinyou Fermentation Microbiology Laboratory, Department of Applied Biological Sciences, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA aut Wolfe Saul Department of Chemistry, Queens University, K7L 3N6, Kingston, Ontario, Canada aut Demain Arnold Fermentation Microbiology Laboratory, Department of Applied Biological Sciences, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA aut Applied Microbiology and Biotechnology Springer-Verlag 29/2-3(1988-09-01), 242-247 0175-7598 29:2-3<242 1988 29 253 https://doi.org/10.1007/BF01982910 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01982910 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Zhang Jinyou Fermentation Microbiology Laboratory, Department of Applied Biological Sciences, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA aut NATIONALLICENCE 700 1- Wolfe Saul Department of Chemistry, Queens University, K7L 3N6, Kingston, Ontario, Canada aut NATIONALLICENCE 700 1- Demain Arnold Fermentation Microbiology Laboratory, Department of Applied Biological Sciences, Massachusetts Institute of Technology, 02139, Cambridge, MA, USA aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer-Verlag 29/2-3(1988-09-01), 242-247 0175-7598 29:2-3<242 1988 29 253 NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00939315 text/html Onlinezugriff via DOI Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE NATIONALLICENCE NL-springer