caa a22 4500 467949891 CHVBK 20180323165702.0 cr unu---uuuuu 170328e19891001xx s 000 0 eng 10.1007/BF02396146 doi (NATIONALLICENCE)springer-10.1007/BF02396146 (NATIONALLICENCE)springer-10.1007/BF00553626 Eze L. Department of Biochemistry, University of Nigeria, Nsukka, Nigeria aut Plasma trehalase activity and diabetes mellitus [Elektronische Daten] [L. Eze] Trehalase is an enzyme which hydrolyzes the disaccharide trehalose, yielding glucose. It is widespread in nature and found in various human tissues as well as in human plasma. The synthesis and degradation of its substrate trehalose have been considered as being implicated in carbohydrate transport mechanisms. Trehalase activity has been examined in both normal subjects and diabetic patients. In the normal subjects, the frequency histogram of the enzyme activity is bimodal, indicating the existence of genetic polymorphism. The proposed model of a single autosomal locus with two alleles has been verified, with 27% of the population tested belonging to the "low-activity” phenotype and 73% being of the "high-activity” phenotype. Males have higher mean plasma trehalase activity than females. Apparently, the reverse appears to be the case in the diabetic subjects. The mean value for all nondiabetics and that of diabetics were computed and the difference was found to be statistically significant (F=7.02,N l=3,N 2=56,P<0.01). An experiment showed that neither the abnormally high concentration of glucose in diabetics nor any other constituent of the diabetic plasma caused an increase in plasma trehalase activity (t=0.0724,P>0.10). A Woolf and Haldane test to determine association of diabetes mellitus and plasma trehalase phenotype indicated a highly significant association with the high-activity phenotype (X2=18.5350,P<0.01). Thus the inference is that people with high plasma trehalase activity are more prone to develop diabetes mellitus than people with low enzyme activity. Plenum Publishing Corporation, 1989 trehalose nationallicence trehalase nationallicence diabetes mellitus nationallicence Biochemical Genetics Kluwer Academic Publishers-Plenum Publishers 27/9-10(1989-10-01), 487-495 0006-2928 27:9-10<487 1989 27 10528 https://doi.org/10.1007/BF02396146 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02396146 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Eze L. Department of Biochemistry, University of Nigeria, Nsukka, Nigeria aut NATIONALLICENCE 773 0- Biochemical Genetics Kluwer Academic Publishers-Plenum Publishers 27/9-10(1989-10-01), 487-495 0006-2928 27:9-10<487 1989 27 10528 NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00553626 text/html Onlinezugriff via DOI Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE NATIONALLICENCE NL-springer