caa a22 4500 467951233 CHVBK 20180405193742.0 cr unu---uuuuu 170328e20050201xx s 000 0 eng 10.1007/s11055-005-0050-0 doi (NATIONALLICENCE)springer-10.1007/s11055-005-0050-0 (NATIONALLICENCE)springer-10.1007/s11055-005-0003-7 Selective involvement of opioids in the mechanisms of synapse-specific plasticity in the common snail during the acquisition of sensitization [Elektronische Daten] [V. Nikitin, S. Kozyrev] Studies on defensive behavior command neurons LPl1 and RPl1 in semi-intact common snail preparations were performed to investigate the effects of the opioid peptide metenkephalin and the opioid antagonist naloxone on the effects of nociceptive sensitization. Application of nociceptive stimuli to the snail's head elicited marked reversible membrane depolarization along with depression of neuron responses to sensory stimulation during the short-term stage of sensitization and facilitation of responses in the long-term stage. Metenkephalin at a dose of 10 µM but not at a dose of 0.1 µM partially suppressed responses to nociceptive stimuli. Acquisition of sensitization during exposure to metenkephalin at doses of 10 and 0.1 µM led to complete suppression of the facilitation of responses to tactile stimulation of the head. Facilitation of responses to chemical stimulation of the head and tactile stimulation of the foot in these conditions was similar to that of neurons in control sensitized animals. Acquisition of sensitization during exposure to metenkephalin and/or naloxone elicited selective suppression of facilitation of responses to chemical stimulation of the head but had no effect on facilitation of responses to tactile stimulation of the head and foot. Met-enkephalin and naloxone had no effect on the depression of neuron responses evoked by sensory stimulation in the short-term stage of sensitization. It is suggested that during the acquisition of sensitization in the common snail, opioids are involved in controlling the mechanism of nociception and in the mechanisms of selective induction of long-term plasticity of the synaptic inputs to command neurons activated by tactile and chemical stimulation of the animal's head. Springer Science+Business Media, Inc., 2005 snail nationallicence neuron nationallicence sensitization nationallicence synapse-specific plasticity nationallicence opioids nationallicence Nikitin V. P. K. Anokhin Science Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow aut Kozyrev S. P. K. Anokhin Science Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow aut Neuroscience and Behavioral Physiology Kluwer Academic Publishers-Consultants Bureau 35/2(2005-02-01), 125-132 0097-0549 35:2<125 2005 35 11055 https://doi.org/10.1007/s11055-005-0050-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11055-005-0050-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nikitin V. P. K. Anokhin Science Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow aut NATIONALLICENCE 700 1- Kozyrev S. P. K. Anokhin Science Research Institute of Normal Physiology, Russian Academy of Medical Sciences, Moscow aut NATIONALLICENCE 773 0- Neuroscience and Behavioral Physiology Kluwer Academic Publishers-Consultants Bureau 35/2(2005-02-01), 125-132 0097-0549 35:2<125 2005 35 11055 NATIONALLICENCE 856 40 https://doi.org/10.1007/s11055-005-0003-7 text/html Onlinezugriff via DOI Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE NATIONALLICENCE NL-springer