caa a22 4500 467951608 CHVBK 20180323165702.0 cr unu---uuuuu 170328e19881201xx s 000 0 eng 10.1007/BF00553870 doi (NATIONALLICENCE)springer-10.1007/BF00553870 (NATIONALLICENCE)springer-10.1007/BF02395517 Specificity of androgen resistance in Mus caroli kidney [Elektronische Daten] [Carol Wilson, Debora Kimberlin, James Griffin, Jean Wilson] Androgen controls the expression of β-glucuronidase and several other proteins in the kidney of the standard laboratory mouse,Mus musculus. Other species within the genusMus exhibit a variety of response patterns for kidney β-glucuronidase and other markers of androgen action. We have investigated the mechanism of androgen action inM. caroli, aMus species that does not produce β-glucuronidase in response to testosterone. The failure of testosterone to induce β-glucuronidase inM. caroli females cannot be overcome by treatment with dihydrotestosterone, with pharmacological doses of testosterone propionate or dihydrotestosterone propionate, or with a variety of potent androgen analogues. All of these compounds induce kidney β-glucuronidase inM. musculus females and kidney ornithine decarboxylase, submandibular gland renin, and submandibular gland epidermal growth factor in bothM. caroli andM. musculus females. Furthermore, kidney androgen receptor proteins fromM. caroli andM. musculus animals have the same sedimentation characteristics on sucrose density gradients. These data indicate that androgen resistance inM. caroli is not due to deficient 5α-reductase or aberrant hormone metabolism producing suboptimal levels of functional androgen and is not caused by a defective androgen receptor. They suggest that the resistance of β-glucuronidase inM. caroli kidney to induction by androgen occurs at the level of the β-glucuronidase gene. Plenum Publishing Corporation, 1988 Mus caroli nationallicence Mus musculus nationallicence androgen nationallicence kidney nationallicence submandibular gland nationallicence Wilson Carol Department of Internal Medicine, University of Texas Southwestern Medical Center, 75235, Dallas, Texas aut Kimberlin Debora Department of Internal Medicine, University of Texas Southwestern Medical Center, 75235, Dallas, Texas aut Griffin James Department of Internal Medicine, University of Texas Southwestern Medical Center, 75235, Dallas, Texas aut Wilson Jean Department of Internal Medicine, University of Texas Southwestern Medical Center, 75235, Dallas, Texas aut Biochemical Genetics Kluwer Academic Publishers-Plenum Publishers 26/11-12(1988-12-01), 705-716 0006-2928 26:11-12<705 1988 26 10528 https://doi.org/10.1007/BF00553870 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00553870 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wilson Carol Department of Internal Medicine, University of Texas Southwestern Medical Center, 75235, Dallas, Texas aut NATIONALLICENCE 700 1- Kimberlin Debora Department of Internal Medicine, University of Texas Southwestern Medical Center, 75235, Dallas, Texas aut NATIONALLICENCE 700 1- Griffin James Department of Internal Medicine, University of Texas Southwestern Medical Center, 75235, Dallas, Texas aut NATIONALLICENCE 700 1- Wilson Jean Department of Internal Medicine, University of Texas Southwestern Medical Center, 75235, Dallas, Texas aut NATIONALLICENCE 773 0- Biochemical Genetics Kluwer Academic Publishers-Plenum Publishers 26/11-12(1988-12-01), 705-716 0006-2928 26:11-12<705 1988 26 10528 NATIONALLICENCE 856 40 https://doi.org/10.1007/BF02395517 text/html Onlinezugriff via DOI Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE NATIONALLICENCE NL-springer