caa a22 4500 467952515 CHVBK 20180323165703.0 cr unu---uuuuu 170328e19880901xx s 000 0 eng 10.1007/BF01982898 doi (NATIONALLICENCE)springer-10.1007/BF01982898 (NATIONALLICENCE)springer-10.1007/BF00939303 Tetracycline production by Streptomyces aureofaciens [Elektronische Daten] the time lag of production [Anton Ross, Karl Schügerl] Summary: The exact time course of phosphate consumption in a tetracycline production byStreptomyces aureofaciens has been determined. The data have been compared with model simulations according to a model proposed by Votruba et al. (1984). This led to a revision of his equation for the rate of phosphate consumption and to the proposal that phosphate is consumed proportionally to the growth rate. In contradiction to the model simulations it was found that the length of the time lag of the production is independent of the initial phosphate concentration. While the model explains the time lag through inhibition of the production by phosphate, the measured data show that there must be another or an additional reason for the lag. Simultaneously with the start of the production the organism changes from an organic substrate to ammonia as nitrogen source. All experiments have been carried out in a bubble column of 651 working volume as fed batch fermentation. An autoanalyzer and a HPLC was coupled to the reactor for automatic measurement of phosphate, ammonia, sucrose and products in short intervals. Composition of the outlet gas, pH, pO2, temperature and weight of the substrate flasks were monitored on-line. Springer-Verlag, 1988 Ross Anton Gesellschaft für Biotechnologische Forschung mbH, Mascheroder Weg 1, D-3300, Braunschweig, Federal Republic o Germany aut Schügerl Karl Institut für Technische Chemie der Universität Hannover, Callinstr. 5, D-3000, Hannover, Federal Republic of Germany aut Applied Microbiology and Biotechnology Springer-Verlag 29/2-3(1988-09-01), 174-180 0175-7598 29:2-3<174 1988 29 253 https://doi.org/10.1007/BF01982898 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01982898 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ross Anton Gesellschaft für Biotechnologische Forschung mbH, Mascheroder Weg 1, D-3300, Braunschweig, Federal Republic o Germany aut NATIONALLICENCE 700 1- Schügerl Karl Institut für Technische Chemie der Universität Hannover, Callinstr. 5, D-3000, Hannover, Federal Republic of Germany aut NATIONALLICENCE 773 0- Applied Microbiology and Biotechnology Springer-Verlag 29/2-3(1988-09-01), 174-180 0175-7598 29:2-3<174 1988 29 253 NATIONALLICENCE 856 40 https://doi.org/10.1007/BF00939303 text/html Onlinezugriff via DOI Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE NATIONALLICENCE NL-springer