caa a22 4500 467954429 CHVBK 20180405193745.0 cr unu---uuuuu 170328e20050101xx s 000 0 eng 10.1007/s10541-005-0054-y doi (NATIONALLICENCE)springer-10.1007/s10541-005-0054-y (NATIONALLICENCE)springer-10.1007/PL00021762 Changes in antioxidant status of myocardium during oxidative stress under the influence of coenzyme Q10 [Elektronische Daten] [V. Lakomkin, G. Konovalova, E. Kalenikova, I. Zabbarova, A. Kaminnyi, A. Tikhaze, V. Lankin, E. Ruuge, V. Kapelko] Changes in myocardium were studied during oxidative stress induced by infusion of hydrogen peroxide in the coronary vessels of isolated rat heart. Moderate concentrations of H2O2 increased the heart rate but decreased the contractile force, whereas higher concentrations of H2O2 decreased both parameters and increased the end diastolic pressure. The effect of H2O2 was stable, cumulative, and was associated with disturbance in respiration of mitochondria, increased production of ROS in them, and decrease in activities of antioxidant enzymes in the myocardium. Changes in the antioxidant status of the myocardium induced by long-term addition of coenzyme Q10 into food was accompanied by decrease in the negative inotropic effect of H2O2, whereas the levels of superoxide dismutase and glutathione peroxidase after oxidative stress were virtually unchanged. The activities of these enzymes displayed a high positive correlation with the cardiac function. The findings suggest that coenzyme Q10 should increase resistance of the myocardium to oxidative stress not only by a direct antioxidant mechanism but also indirectly, due to increased protection of antioxidant enzymes. MAIK "Nauka/Interperiodica”, 2005 isolated heart nationallicence antioxidant protection nationallicence oxidative stress nationallicence mitochondria nationallicence coenzyme Q10 nationallicence hydrogen peroxide nationallicence Lakomkin V. Russian Research and Productive Cardiology Complex, Ministry of Health of Russian Federation, 3-ya Cherepkovskaya ul. 15A, 121552, Moscow, Russia aut Konovalova G. Russian Research and Productive Cardiology Complex, Ministry of Health of Russian Federation, 3-ya Cherepkovskaya ul. 15A, 121552, Moscow, Russia aut Kalenikova E. Russian Research and Productive Cardiology Complex, Ministry of Health of Russian Federation, 3-ya Cherepkovskaya ul. 15A, 121552, Moscow, Russia aut Zabbarova I. Russian Research and Productive Cardiology Complex, Ministry of Health of Russian Federation, 3-ya Cherepkovskaya ul. 15A, 121552, Moscow, Russia aut Kaminnyi A. Russian Research and Productive Cardiology Complex, Ministry of Health of Russian Federation, 3-ya Cherepkovskaya ul. 15A, 121552, Moscow, Russia aut Tikhaze A. Russian Research and Productive Cardiology Complex, Ministry of Health of Russian Federation, 3-ya Cherepkovskaya ul. 15A, 121552, Moscow, Russia aut Lankin V. Russian Research and Productive Cardiology Complex, Ministry of Health of Russian Federation, 3-ya Cherepkovskaya ul. 15A, 121552, Moscow, Russia aut Ruuge E. Russian Research and Productive Cardiology Complex, Ministry of Health of Russian Federation, 3-ya Cherepkovskaya ul. 15A, 121552, Moscow, Russia aut Kapelko V. Russian Research and Productive Cardiology Complex, Ministry of Health of Russian Federation, 3-ya Cherepkovskaya ul. 15A, 121552, Moscow, Russia aut Biochemistry (Moscow) Nauka/Interperiodica 70/1(2005-01-01), 79-84 0006-2979 70:1<79 2005 70 10541 https://doi.org/10.1007/s10541-005-0054-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10541-005-0054-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lakomkin V. Russian Research and Productive Cardiology Complex, Ministry of Health of Russian Federation, 3-ya Cherepkovskaya ul. 15A, 121552, Moscow, Russia aut NATIONALLICENCE 700 1- Konovalova G. Russian Research and Productive Cardiology Complex, Ministry of Health of Russian Federation, 3-ya Cherepkovskaya ul. 15A, 121552, Moscow, Russia aut NATIONALLICENCE 700 1- Kalenikova E. Russian Research and Productive Cardiology Complex, Ministry of Health of Russian Federation, 3-ya Cherepkovskaya ul. 15A, 121552, Moscow, Russia aut NATIONALLICENCE 700 1- Zabbarova I. Russian Research and Productive Cardiology Complex, Ministry of Health of Russian Federation, 3-ya Cherepkovskaya ul. 15A, 121552, Moscow, Russia aut NATIONALLICENCE 700 1- Kaminnyi A. Russian Research and Productive Cardiology Complex, Ministry of Health of Russian Federation, 3-ya Cherepkovskaya ul. 15A, 121552, Moscow, Russia aut NATIONALLICENCE 700 1- Tikhaze A. Russian Research and Productive Cardiology Complex, Ministry of Health of Russian Federation, 3-ya Cherepkovskaya ul. 15A, 121552, Moscow, Russia aut NATIONALLICENCE 700 1- Lankin V. Russian Research and Productive Cardiology Complex, Ministry of Health of Russian Federation, 3-ya Cherepkovskaya ul. 15A, 121552, Moscow, Russia aut NATIONALLICENCE 700 1- Ruuge E. Russian Research and Productive Cardiology Complex, Ministry of Health of Russian Federation, 3-ya Cherepkovskaya ul. 15A, 121552, Moscow, Russia aut NATIONALLICENCE 700 1- Kapelko V. Russian Research and Productive Cardiology Complex, Ministry of Health of Russian Federation, 3-ya Cherepkovskaya ul. 15A, 121552, Moscow, Russia aut NATIONALLICENCE 773 0- Biochemistry (Moscow) Nauka/Interperiodica 70/1(2005-01-01), 79-84 0006-2979 70:1<79 2005 70 10541 NATIONALLICENCE 856 40 https://doi.org/10.1007/PL00021762 text/html Onlinezugriff via DOI Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer NATIONALLICENCE NATIONALLICENCE NL-springer