caa a22 4500 467978921 CHVBK 20180323112513.0 cr unu---uuuuu 170328e19901101xx s 000 0 eng 10.1007/BF01974696 doi (NATIONALLICENCE)springer-10.1007/BF01974696 Subclinical effects of groundwater contaminants. IV. Effects of repeated oral exposure to combinations of benzene and toluene on regional brain monoamine metabolism in mice [Elektronische Daten] [Gin Hsieh, Raghubir Sharma, Robert Parker] Benzene and toluene are known neurotoxicants that may interact in vivo. The effect of combined treatment with benzene and toluene on the endogenous concentrations of the catecholamines norepinephrine (NE) and dopamine (DA), the catecholamine metabolites vanillylmandelic acid (VMA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), and the indoleamine serotonin (5-HT) and its metabolite 5-hydroxyindoleacetic acid (5-HIAA), were investigated in six discrete brain regions of CD-1 mice. Groups of male, adult mice were continuously exposed to benzene (166 mg/l), toluene (80 and 325 mg/l), and combinations of benzene + toluene (80 or 325 mg/l) in drinking water for 4 weeks. Benzene produced increases of NE in the hypothalamus, cortex, midbrain and medulla oblongata, DA in the hypothalamus and corpus striatum, and 5-HT in all dissected brain regions except cerebellum. Elevated levels of various monoamine metabolites were also observed in these brain areas. Toluene ingestion alone also significantly increased the concentrations of NE, DA, 5-HT, and their metabolites in several brain regions. Mice given the combined treatments exhibited raised regional neurochemical levels when compared to the untreated controls. Increased concentrations of biogenic amine metabolites in several brain regions were greater in the combined exposures of benzene and toluene than when either chemical was used alone. The findings were different from those observed on immune parameters using similar treatment protocols, where simultaneous exposure to toluene prevented the immunotoxic effects of benzene. Springer-Verlag, 1990 Benzene nationallicence Toluene nationallicence Solvent interactions nationallicence Immunotoxicology nationallicence Biogenic amines nationallicence Hsieh Gin Toxicology, Center for Environmental, Department of Biology, Utah State University, 84 322, Logan, UT aut Sharma Raghubir Toxicology, Center for Environmental, Department of Animal, Dairy & Veterinary Sciences, Utah State University, 84 322, Logan, UT aut Parker Robert Toxicology, Center for Environmental, Department of Biology, Utah State University, 84 322, Logan, UT aut Archives of Toxicology Springer-Verlag 64/8(1990-11-01), 669-676 0340-5761 64:8<669 1990 64 204 https://doi.org/10.1007/BF01974696 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01974696 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Hsieh Gin Toxicology, Center for Environmental, Department of Biology, Utah State University, 84 322, Logan, UT aut NATIONALLICENCE 700 1- Sharma Raghubir Toxicology, Center for Environmental, Department of Animal, Dairy & Veterinary Sciences, Utah State University, 84 322, Logan, UT aut NATIONALLICENCE 700 1- Parker Robert Toxicology, Center for Environmental, Department of Biology, Utah State University, 84 322, Logan, UT aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 64/8(1990-11-01), 669-676 0340-5761 64:8<669 1990 64 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 465902278 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer