caa a22 4500 46797893X CHVBK 20180323112514.0 cr unu---uuuuu 170328e19901101xx s 000 0 eng 10.1007/BF01974692 doi (NATIONALLICENCE)springer-10.1007/BF01974692 Acute toxic effect of sodium dichromate on metabolism [Elektronische Daten] [Eun Kim, Ki Na] The effect of sodium dichromate on cellular metabolism was investigated. Intraperitoneal injection of sodium dichromate into the rat (20 or 40 mg/kg) caused significant increases in serum lactate, pyruvate, and creatinine concentrations within 15 min after intoxication. Severe hyperglycemia occurred thereafter, as a result of increased hepatic glycogenolysis, which was seen in the first 2 h after dichromate. However, liver glycogen was resynthesized in 24 h-fasted rats after glucose refeeding. Dichromate decreased serum total amino acids, with a consequent increase in blood urea nitrogen (BUN) concentration. Unlike HgCl2 (2 mg/kg, i.p.), As2O3 (5 mg/kg, i.p.), and KCN (5 mg/kg, i. p.), dichromate showed the largest metabolic disturbance only in the early period after treatment. In addition, dichromate produced cyanosis, which appeared during the period of the accelerated glycolysis and breakdown of creatine phosphate. Regardless of chemical species, only the hexavalent chromium compounds had an effect on the cellular metabolism. Trivalent chromium compounds had no effect at all. These results suggest that dichromate possesses a characteristic dual action on cellular metabolism, which might be related to its metabolic fate. Springer-Verlag, 1990 Sodium dichromate nationallicence Glycolysis nationallicence Hyperglycemia nationallicence Glycogenolysis nationallicence Cyanosis nationallicence Kim Eun Korea Ginseng and Tobacco Research Institute, 302 Shinsung-dong, Yousung-ku, 305-345, Taejon, Korea aut Na Ki Korea Ginseng and Tobacco Research Institute, 302 Shinsung-dong, Yousung-ku, 305-345, Taejon, Korea aut Archives of Toxicology Springer-Verlag 64/8(1990-11-01), 644-649 0340-5761 64:8<644 1990 64 204 https://doi.org/10.1007/BF01974692 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01974692 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kim Eun Korea Ginseng and Tobacco Research Institute, 302 Shinsung-dong, Yousung-ku, 305-345, Taejon, Korea aut NATIONALLICENCE 700 1- Na Ki Korea Ginseng and Tobacco Research Institute, 302 Shinsung-dong, Yousung-ku, 305-345, Taejon, Korea aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 64/8(1990-11-01), 644-649 0340-5761 64:8<644 1990 64 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer