caa a22 4500 467978948 CHVBK 20180323112514.0 cr unu---uuuuu 170328e19901101xx s 000 0 eng 10.1007/BF01974697 doi (NATIONALLICENCE)springer-10.1007/BF01974697 Alteration of rat liver microsomal monooxygenase activities by gasoline treatment [Elektronische Daten] [John Brady, Fang Xiao, Jeanne Gapac, Shu Ning, Chung Yang] Previous work has shown an increase in rat liver enzyme activities after chronic exposure to gasoline vapor. In the present study, male Sprague-Dawley rats were pretreated with unleaded gasoline at 1 and 5 ml/kg, i.p., and selected hepatic microsomal monooxygenase activities were determined at 18, 48, and 72 h. At 18 h, moderate increases were observed in P450 content (1.3-fold), cytochromec-reductase activity (1.25-fold), and inN-nitrosodimethylamine demethylation rate (1.25- to 1.6-fold). Pentoxyresorufin dealkylase activity (an activity displayed primarily by P450IIB1) was significantly elevated at 18 and 48 h (30- to 60-fold), and ethoxyresorufin dealkylase activity (an activity displayed by P450 IA1) was elevated (2- to 4-fold). Immunoblot analysis revealed no change in P450IIE1 at these time points, but an elevation in P450IIB1 in agreement with the pentoxyresorufin dealkylase activity measurements. Springer-Verlag, 1990 Gasoline nationallicence Rat nationallicence Liver nationallicence Microsomal mono- oxygenase activity nationallicence Brady John Department of Chemical Biology and Pharmacognosy, College of Pharmacy, Rutgers University, 08 855, Piscataway, NJ, USA aut Xiao Fang Department of Chemical Biology and Pharmacognosy, College of Pharmacy, Rutgers University, 08 855, Piscataway, NJ, USA aut Gapac Jeanne Department of Chemical Biology and Pharmacognosy, College of Pharmacy, Rutgers University, 08 855, Piscataway, NJ, USA aut Ning Shu Department of Chemical Biology and Pharmacognosy, College of Pharmacy, Rutgers University, 08 855, Piscataway, NJ, USA aut Yang Chung Department of Chemical Biology and Pharmacognosy, College of Pharmacy, Rutgers University, 08 855, Piscataway, NJ, USA aut Archives of Toxicology Springer-Verlag 64/8(1990-11-01), 677-679 0340-5761 64:8<677 1990 64 204 https://doi.org/10.1007/BF01974697 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01974697 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Brady John Department of Chemical Biology and Pharmacognosy, College of Pharmacy, Rutgers University, 08 855, Piscataway, NJ, USA aut NATIONALLICENCE 700 1- Xiao Fang Department of Chemical Biology and Pharmacognosy, College of Pharmacy, Rutgers University, 08 855, Piscataway, NJ, USA aut NATIONALLICENCE 700 1- Gapac Jeanne Department of Chemical Biology and Pharmacognosy, College of Pharmacy, Rutgers University, 08 855, Piscataway, NJ, USA aut NATIONALLICENCE 700 1- Ning Shu Department of Chemical Biology and Pharmacognosy, College of Pharmacy, Rutgers University, 08 855, Piscataway, NJ, USA aut NATIONALLICENCE 700 1- Yang Chung Department of Chemical Biology and Pharmacognosy, College of Pharmacy, Rutgers University, 08 855, Piscataway, NJ, USA aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 64/8(1990-11-01), 677-679 0340-5761 64:8<677 1990 64 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer