caa a22 4500 467978972 CHVBK 20180323112514.0 cr unu---uuuuu 170328e19901101xx s 000 0 eng 10.1007/BF01974689 doi (NATIONALLICENCE)springer-10.1007/BF01974689 Teratogenicity of arotinoids (retinoids) in vivo and in vitro [Elektronische Daten] [Andreas Kistler, Toshie Tsuchiya, Masahiko Tsuchiya, Michael Klaus] The effect of structural modifications on the arotinoid molecule, a new class of retinoids, on their teratogenicity in mice was studied. Animals were treated on days 8 and 9 of gestation, the most susceptible stages to retinoid-induced malformations in rodents. The teratogenic potency of the 13 arotinoids tested varied over a dose range of more than five orders of magnitude. Next, we tested whether the quantitative differences in the teratogenicity of these arotinoids correlates with their activity in high density (micromass) cultures of rat embryonic limb bud and midbrain cells. There was a good quantitative correlation between the in vivo teratogenicity and the in vitro activity in limb bud cells but no correlation was found in midbrain cells. Thus, the limb bud cell culture system may be useful for a preliminary testing to select non-teratogenic retinoids. For the risk assessment in humans, however, the in vitro results should be verified in animals studies. Springer-Verlag, 1990 Teratogenicity in vivo nationallicence Teratogenicity in vitro nationallicence Retinoids nationallicence Arotinoids nationallicence Micromass culture nationallicence Kistler Andreas Phamaceutical Research, F. Hoffmann-La Roche Ltd, 4002, Basel aut Tsuchiya Toshie Faculty of Veterinary Medicine, University of Berne, 3000, Bern, Switzerland aut Tsuchiya Masahiko Phamaceutical Research, F. Hoffmann-La Roche Ltd, 4002, Basel aut Klaus Michael Phamaceutical Research, F. Hoffmann-La Roche Ltd, 4002, Basel aut Archives of Toxicology Springer-Verlag 64/8(1990-11-01), 616-622 0340-5761 64:8<616 1990 64 204 https://doi.org/10.1007/BF01974689 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01974689 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kistler Andreas Phamaceutical Research, F. Hoffmann-La Roche Ltd, 4002, Basel aut NATIONALLICENCE 700 1- Tsuchiya Toshie Faculty of Veterinary Medicine, University of Berne, 3000, Bern, Switzerland aut NATIONALLICENCE 700 1- Tsuchiya Masahiko Phamaceutical Research, F. Hoffmann-La Roche Ltd, 4002, Basel aut NATIONALLICENCE 700 1- Klaus Michael Phamaceutical Research, F. Hoffmann-La Roche Ltd, 4002, Basel aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 64/8(1990-11-01), 616-622 0340-5761 64:8<616 1990 64 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer