caa a22 4500 467979006 CHVBK 20180323112514.0 cr unu---uuuuu 170328e19900701xx s 000 0 eng 10.1007/BF01973467 doi (NATIONALLICENCE)springer-10.1007/BF01973467 The influence of carbaryl on the uptake of (3H)-noradrenaline (3H)-NA by rat hypothalamic slices [Elektronische Daten] [Joanna Jablońska, Jacek Brzeziński] The uptake of (3H)-NA by rat hypothalamic slices was investigated following carbaryl poisoning. The insecticide was administered to rats orally in a single dose of 50% LD50 and of 20% LD50, and in repeated dosing for 14 days (5% LD50 daily). The kinetics of (3H)-NA uptake was defined by the modified Lineweaver-Burk plots (Rmax was used instead of Vmax and Km was replaced with t05 max). The results indicated that in all the experiments carbaryl elevated the (3H)-NA uptake by hypothalamic slices in a dosage dependent fashion (insignificantly at the 20% LD50 dose level,p >0.05) as evidenced by the increased Rmax values. However, carbaryl simultaneously decreased the kinetics of the process in the hypothalamus since t0.5max values were enhanced (insignificantly at the 5% LD50 dose level,p >0.05). Carbaryl produced a dosedependent increase of t0.5max values. The changes in the (3H)-NA uptake may be related to the increase of NA level in the hypothalamus following exposure to carbaryl observed by other authors. Springer-Verlag, 1990 Carbaryl nationallicence Noradrenaline nationallicence Uptake nationallicence Hypothalamus-Kinetics nationallicence Jablońska Joanna Department of Toxicology, Medical Academy Warsaw, 1 Banacha Street, PL-02-097, Warsaw, Poland aut Brzeziński Jacek Department of Toxicology, Medical Academy Warsaw, 1 Banacha Street, PL-02-097, Warsaw, Poland aut Archives of Toxicology Springer-Verlag 64/5(1990-07-01), 417-419 0340-5761 64:5<417 1990 64 204 https://doi.org/10.1007/BF01973467 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/BF01973467 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Jablońska Joanna Department of Toxicology, Medical Academy Warsaw, 1 Banacha Street, PL-02-097, Warsaw, Poland aut NATIONALLICENCE 700 1- Brzeziński Jacek Department of Toxicology, Medical Academy Warsaw, 1 Banacha Street, PL-02-097, Warsaw, Poland aut NATIONALLICENCE 773 0- Archives of Toxicology Springer-Verlag 64/5(1990-07-01), 417-419 0340-5761 64:5<417 1990 64 204 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer